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- NCIT_C160706 IAO_0000115 "An orally available inhibitor of histone deacetylase (HDAC) classes I and IIb with potential antineoplastic activities. Upon oral administration, HDAC I/IIb inhibitor HG146 selectively inhibits the catalytic activity of class I and IIb HDACs, which results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibits tumor cell division and induces tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Class I HDACs are located in the nucleus and include HDACs 1, 2, 3, and 8; class IIb HDACs include HDAC 6 and 10 and are located in both the nucleus and the cytoplasm." @default.
- NCIT_C160706 NCIT_A32 NCIT_C1909 @default.
- NCIT_C160706 NCIT_NHC0 "C160706" @default.
- NCIT_C160706 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160706 NCIT_P108 "HDAC Class I/IIb Inhibitor HG146" @default.
- NCIT_C160706 NCIT_P208 "CL969804" @default.
- NCIT_C160706 NCIT_P322 "GDC" @default.
- NCIT_C160706 NCIT_P329 "797880" @default.
- NCIT_C160706 NCIT_P330 "797880" @default.
- NCIT_C160706 NCIT_P375 "HDAC Class I/IIb Inhibitor HG146" @default.
- NCIT_C160706 NCIT_P399 "797880" @default.
- NCIT_C160706 normalizedInformationContent "100" @default.
- NCIT_C160706 referenceCount "1" @default.
- NCIT_C160706 hasExactSynonym "Class I/IIb HDACi HG146" @default.
- NCIT_C160706 hasExactSynonym "HDAC Class I/IIb Inhibitor HG146" @default.
- NCIT_C160706 hasExactSynonym "HDAC I/IIb Selective Inhibitor HG146" @default.
- NCIT_C160706 hasExactSynonym "HG 146" @default.
- NCIT_C160706 hasExactSynonym "HG-146" @default.
- NCIT_C160706 hasExactSynonym "HG0146" @default.
- NCIT_C160706 hasExactSynonym "HG146" @default.
- NCIT_C160706 hasExactSynonym "HG280146" @default.
- NCIT_C160706 hasExactSynonym "HG280146-P1" @default.
- NCIT_C160706 inSubset NCIT_C128784 @default.
- NCIT_C160706 inSubset NCIT_C157711 @default.
- NCIT_C160706 inSubset NCIT_C157712 @default.
- NCIT_C160706 inSubset NCIT_C176424 @default.
- NCIT_C160706 inSubset NCIT_C177537 @default.
- NCIT_C160706 type Class @default.
- NCIT_C160706 isDefinedBy ncit.owl @default.
- NCIT_C160706 label "HDAC Class I/IIb Inhibitor HG146" @default.
- NCIT_C160706 subClassOf NCIT_C129824 @default.
- NCIT_C160706 subClassOf NCIT_C129825 @default.
- NCIT_C160706 subClassOf NCIT_C160706 @default.
- NCIT_C160706 subClassOf NCIT_C163758 @default.
- NCIT_C160706 subClassOf NCIT_C1908 @default.
- NCIT_C160706 subClassOf NCIT_C1909 @default.
- NCIT_C160706 subClassOf NCIT_C1946 @default.
- NCIT_C160706 subClassOf NCIT_C2189 @default.
- NCIT_C160706 subClassOf NCIT_C274 @default.
- NCIT_C160706 subClassOf NCIT_C471 @default.