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- NCIT_C160711 IAO_0000115 "A preparation of autologous central memory-enriched T-cells (Tcm) that have been transduced with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) comprised of a CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC)-specific single chain variable fragment (scFV), fused to the costimulatory signaling domain of 4-1BB (CD137), and a truncated human epidermal growth factor receptor (huEGFRt), with potential antineoplastic activity. Upon intravenous infusion, anti-CS1-CAR-4-1BB-CD3z-EGFRt-expressing Tcm-enriched T-lymphocytes target and induce selective toxicity in CS-1-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed huEGFRt facilitates both in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. CS1, a cell surface glycoprotein of the signaling lymphocyte activation molecule (SLAM) receptor family, is highly expressed on certain malignant plasma cells." @default.
- NCIT_C160711 NCIT_NHC0 "C160711" @default.
- NCIT_C160711 NCIT_P106 "Cell" @default.
- NCIT_C160711 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160711 NCIT_P108 "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells" @default.
- NCIT_C160711 NCIT_P208 "CL969815" @default.
- NCIT_C160711 NCIT_P329 "797881" @default.
- NCIT_C160711 NCIT_P330 "797881" @default.
- NCIT_C160711 NCIT_P399 "797881" @default.
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- NCIT_C160711 normalizedInformationContent "100" @default.
- NCIT_C160711 referenceCount "1" @default.
- NCIT_C160711 hasExactSynonym "Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched Autologous T-cells" @default.
- NCIT_C160711 hasExactSynonym "Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched Autologous T-lymphocytes" @default.
- NCIT_C160711 hasExactSynonym "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells" @default.
- NCIT_C160711 hasExactSynonym "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-lymphocytes" @default.
- NCIT_C160711 hasExactSynonym "CS1-CAR T-cells" @default.
- NCIT_C160711 hasExactSynonym "CS1-CAR T-lymphocytes" @default.
- NCIT_C160711 inSubset NCIT_C128784 @default.
- NCIT_C160711 inSubset NCIT_C176424 @default.
- NCIT_C160711 type Class @default.
- NCIT_C160711 isDefinedBy ncit.owl @default.
- NCIT_C160711 label "Autologous Anti-CS1 Hinge-optimized CAR-4-1BB-EGFRt-expressing Memory-enriched T-cells" @default.
- NCIT_C160711 subClassOf NCIT_C129820 @default.
- NCIT_C160711 subClassOf NCIT_C129821 @default.
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- NCIT_C160711 subClassOf NCIT_C137999 @default.
- NCIT_C160711 subClassOf NCIT_C142078 @default.
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- NCIT_C160711 subClassOf NCIT_C160711 @default.
- NCIT_C160711 subClassOf NCIT_C1908 @default.
- NCIT_C160711 subClassOf NCIT_C1909 @default.
- NCIT_C160711 subClassOf NCIT_C1962 @default.
- NCIT_C160711 subClassOf NCIT_C200766 @default.
- NCIT_C160711 subClassOf NCIT_C274 @default.
- NCIT_C160711 subClassOf NCIT_C28681 @default.
- NCIT_C160711 subClassOf NCIT_C307 @default.
- NCIT_C160711 subClassOf NCIT_C308 @default.