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- NCIT_C160780 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically engineered to express a single-domain antibody that recognizes human mesothelin, fused to the N-terminus of the CD3-epsilon T-cell receptor (TCR) subunit which, upon expression is incorporated into the endogenous TCR complex, with potential antineoplastic activity. Upon administration, gavocabtagene autoleucel specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. Compared to chimeric antigen receptor (CAR) T-cells, TRuCs may be associated with less pro-inflammatory cytokine secretion and fewer adverse effects without compromising therapeutic efficacy." @default.
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- NCIT_C160780 NCIT_P106 "Cell" @default.
- NCIT_C160780 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160780 NCIT_P107 "Gavocabtagene Autoleucel" @default.
- NCIT_C160780 NCIT_P108 "Gavocabtagene Autoleucel" @default.
- NCIT_C160780 NCIT_P208 "CL969765" @default.
- NCIT_C160780 NCIT_P319 "NP6CFH3G8H" @default.
- NCIT_C160780 NCIT_P322 "CTRP" @default.
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- NCIT_C160780 NCIT_P329 "798416" @default.
- NCIT_C160780 NCIT_P330 "798416" @default.
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- NCIT_C160780 NCIT_R72 NCIT_C104083 @default.
- NCIT_C160780 NCIT_R72 NCIT_C12219 @default.
- NCIT_C160780 NCIT_R72 NCIT_C12476 @default.
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- NCIT_C160780 NCIT_R72 NCIT_C12535 @default.
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- NCIT_C160780 NCIT_R72 NCIT_C39567 @default.
- NCIT_C160780 NCIT_R72 NCIT_C39568 @default.
- NCIT_C160780 normalizedInformationContent "100" @default.
- NCIT_C160780 referenceCount "1" @default.
- NCIT_C160780 hasExactSynonym "Autologous Anti-mesothelin T-cell Receptor Fusion Construct T-cells TC-210" @default.
- NCIT_C160780 hasExactSynonym "Autologous Anti-mesothelin TRuC T-cells TC-210" @default.
- NCIT_C160780 hasExactSynonym "GAVOCABTAGENE AUTOLEUCEL" @default.
- NCIT_C160780 hasExactSynonym "Gavo-cel" @default.
- NCIT_C160780 hasExactSynonym "Gavocabtagene Autoleucel" @default.
- NCIT_C160780 hasExactSynonym "TC 210" @default.
- NCIT_C160780 hasExactSynonym "TC-210 T Cells" @default.
- NCIT_C160780 hasExactSynonym "TC-210" @default.
- NCIT_C160780 hasExactSynonym "TC210" @default.
- NCIT_C160780 inSubset NCIT_C116977 @default.
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- NCIT_C160780 inSubset NCIT_C128784 @default.
- NCIT_C160780 inSubset NCIT_C176424 @default.
- NCIT_C160780 inSubset NCIT_C63923 @default.
- NCIT_C160780 type Class @default.
- NCIT_C160780 isDefinedBy ncit.owl @default.
- NCIT_C160780 label "Gavocabtagene Autoleucel" @default.
- NCIT_C160780 subClassOf NCIT_C129820 @default.
- NCIT_C160780 subClassOf NCIT_C129821 @default.
- NCIT_C160780 subClassOf NCIT_C129826 @default.
- NCIT_C160780 subClassOf NCIT_C142078 @default.
- NCIT_C160780 subClassOf NCIT_C160780 @default.
- NCIT_C160780 subClassOf NCIT_C1908 @default.
- NCIT_C160780 subClassOf NCIT_C1909 @default.
- NCIT_C160780 subClassOf NCIT_C274 @default.
- NCIT_C160780 subClassOf NCIT_C28681 @default.
- NCIT_C160780 subClassOf NCIT_C307 @default.
- NCIT_C160780 subClassOf NCIT_C308 @default.