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- NCIT_C1610 IAO_0000115 "A semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization." @default.
- NCIT_C1610 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1610 NCIT_NHC0 "C1610" @default.
- NCIT_C1610 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1610 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1610 NCIT_P108 "Lurtotecan" @default.
- NCIT_C1610 NCIT_P171 "15571957" @default.
- NCIT_C1610 NCIT_P207 "C0293658" @default.
- NCIT_C1610 NCIT_P210 "149882-10-0" @default.
- NCIT_C1610 NCIT_P319 "4J1L80T08I" @default.
- NCIT_C1610 NCIT_P322 "FDA" @default.
- NCIT_C1610 NCIT_P322 "GDC" @default.
- NCIT_C1610 NCIT_P325 "An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors." @default.
- NCIT_C1610 NCIT_P329 "42331" @default.
- NCIT_C1610 NCIT_P330 "42331" @default.
- NCIT_C1610 NCIT_P350 "C28H30N4O6" @default.
- NCIT_C1610 NCIT_P366 "Lurtotecan" @default.
- NCIT_C1610 NCIT_P375 "Lurtotecan" @default.
- NCIT_C1610 NCIT_P399 "42331" @default.
- NCIT_C1610 normalizedInformationContent "100" @default.
- NCIT_C1610 referenceCount "1" @default.
- NCIT_C1610 hasExactSynonym "7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin" @default.
- NCIT_C1610 hasExactSynonym "GG 211" @default.
- NCIT_C1610 hasExactSynonym "GI147211" @default.
- NCIT_C1610 hasExactSynonym "LURTOTECAN" @default.
- NCIT_C1610 hasExactSynonym "Lurtotecan" @default.
- NCIT_C1610 hasExactSynonym "lurtotecan" @default.
- NCIT_C1610 inSubset NCIT_C128784 @default.
- NCIT_C1610 inSubset NCIT_C157711 @default.
- NCIT_C1610 inSubset NCIT_C157712 @default.
- NCIT_C1610 inSubset NCIT_C176424 @default.
- NCIT_C1610 inSubset NCIT_C177537 @default.
- NCIT_C1610 inSubset NCIT_C63923 @default.
- NCIT_C1610 type Class @default.
- NCIT_C1610 isDefinedBy ncit.owl @default.
- NCIT_C1610 label "Lurtotecan" @default.
- NCIT_C1610 subClassOf NCIT_C129824 @default.
- NCIT_C1610 subClassOf NCIT_C129825 @default.
- NCIT_C1610 subClassOf NCIT_C1610 @default.
- NCIT_C1610 subClassOf NCIT_C1748 @default.
- NCIT_C1610 subClassOf NCIT_C1904 @default.
- NCIT_C1610 subClassOf NCIT_C1908 @default.
- NCIT_C1610 subClassOf NCIT_C1909 @default.
- NCIT_C1610 subClassOf NCIT_C2189 @default.
- NCIT_C1610 subClassOf NCIT_C274 @default.
- NCIT_C1610 subClassOf NCIT_C2843 @default.
- NCIT_C1610 subClassOf NCIT_C471 @default.