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- NCIT_C1617 IAO_0000115 "An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI)" @default.
- NCIT_C1617 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1617 NCIT_NHC0 "C1617" @default.
- NCIT_C1617 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1617 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1617 NCIT_P108 "BR96-Doxorubicin Immunoconjugate" @default.
- NCIT_C1617 NCIT_P207 "C0295525" @default.
- NCIT_C1617 NCIT_P322 "GDC" @default.
- NCIT_C1617 NCIT_P329 "38477" @default.
- NCIT_C1617 NCIT_P330 "38477" @default.
- NCIT_C1617 NCIT_P366 "BR96-Doxorubicin_Immunoconjugate" @default.
- NCIT_C1617 NCIT_P375 "BR96-Doxorubicin Immunoconjugate" @default.
- NCIT_C1617 NCIT_P399 "38477" @default.
- NCIT_C1617 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1617 referenceCount "3" @default.
- NCIT_C1617 hasExactSynonym "BMS-182248-01" @default.
- NCIT_C1617 hasExactSynonym "BR96-DOX immunoconjugate" @default.
- NCIT_C1617 hasExactSynonym "BR96-DOX" @default.
- NCIT_C1617 hasExactSynonym "BR96-Doxorubicin Conjugate" @default.
- NCIT_C1617 hasExactSynonym "BR96-Doxorubicin Immunoconjugate" @default.
- NCIT_C1617 hasExactSynonym "BR96-Doxorubicin" @default.
- NCIT_C1617 hasExactSynonym "SGN-15" @default.
- NCIT_C1617 hasExactSynonym "cBR96-Doxorubicin Immunoconjugate" @default.
- NCIT_C1617 inSubset NCIT_C128784 @default.
- NCIT_C1617 inSubset NCIT_C157711 @default.
- NCIT_C1617 inSubset NCIT_C157712 @default.
- NCIT_C1617 inSubset NCIT_C176424 @default.
- NCIT_C1617 inSubset NCIT_C177537 @default.
- NCIT_C1617 type Class @default.
- NCIT_C1617 isDefinedBy ncit.owl @default.
- NCIT_C1617 label "BR96-Doxorubicin Immunoconjugate" @default.
- NCIT_C1617 subClassOf NCIT_C129821 @default.
- NCIT_C1617 subClassOf NCIT_C129823 @default.
- NCIT_C1617 subClassOf NCIT_C1512 @default.
- NCIT_C1617 subClassOf NCIT_C1617 @default.
- NCIT_C1617 subClassOf NCIT_C1908 @default.
- NCIT_C1617 subClassOf NCIT_C1909 @default.
- NCIT_C1617 subClassOf NCIT_C274 @default.
- NCIT_C1617 subClassOf NCIT_C307 @default.
- NCIT_C1617 subClassOf NCIT_C308 @default.