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- NCIT_C161798 IAO_0000115 "An orally available, selective inhibitor of non-receptor tyrosine-protein kinase TYK2 (tyrosine kinase 2) and tyrosine-protein kinase JAK1 (Janus kinase 1; JAK1) with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, brepocitinib selectively binds to and inhibits the activation of TYK2 and JAK1, thereby disrupting TYK2 and JAK-1-dependent cytokine signaling. This may reduce inflammatory responses and prevent inflammation-induced damage caused by certain immunological diseases. TYK2 and JAK-1 are members of the Janus kinase family of non-receptor tyrosine kinases and are involved in signaling pathways affecting hematopoiesis, immunity and inflammation." @default.
- NCIT_C161798 NCIT_A7 NCIT_C101548 @default.
- NCIT_C161798 NCIT_A7 NCIT_C28493 @default.
- NCIT_C161798 NCIT_NHC0 "C161798" @default.
- NCIT_C161798 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C161798 NCIT_P107 "Brepocitinib" @default.
- NCIT_C161798 NCIT_P108 "Brepocitinib" @default.
- NCIT_C161798 NCIT_P208 "CL970417" @default.
- NCIT_C161798 NCIT_P210 "1883299-62-4" @default.
- NCIT_C161798 NCIT_P319 "3X8387Q25N" @default.
- NCIT_C161798 NCIT_P322 "CTRP" @default.
- NCIT_C161798 NCIT_P322 "FDA" @default.
- NCIT_C161798 NCIT_P329 "798452" @default.
- NCIT_C161798 NCIT_P330 "798452" @default.
- NCIT_C161798 NCIT_P399 "798452" @default.
- NCIT_C161798 normalizedInformationContent "100" @default.
- NCIT_C161798 referenceCount "1" @default.
- NCIT_C161798 hasExactSynonym "BREPOCITINIB" @default.
- NCIT_C161798 hasExactSynonym "Brepocitinib" @default.
- NCIT_C161798 hasExactSynonym "PF 06700841" @default.
- NCIT_C161798 hasExactSynonym "PF-06700841" @default.
- NCIT_C161798 hasExactSynonym "PF-841" @default.
- NCIT_C161798 hasExactSynonym "PF06700841" @default.
- NCIT_C161798 hasExactSynonym "TYK2/JAK1 Inhibitor PF-06700841" @default.
- NCIT_C161798 inSubset NCIT_C116977 @default.
- NCIT_C161798 inSubset NCIT_C116978 @default.
- NCIT_C161798 inSubset NCIT_C176424 @default.
- NCIT_C161798 inSubset NCIT_C63923 @default.
- NCIT_C161798 type Class @default.
- NCIT_C161798 isDefinedBy ncit.owl @default.
- NCIT_C161798 label "Brepocitinib" @default.
- NCIT_C161798 subClassOf NCIT_C129824 @default.
- NCIT_C161798 subClassOf NCIT_C129825 @default.
- NCIT_C161798 subClassOf NCIT_C1404 @default.
- NCIT_C161798 subClassOf NCIT_C161798 @default.
- NCIT_C161798 subClassOf NCIT_C172200 @default.
- NCIT_C161798 subClassOf NCIT_C1908 @default.
- NCIT_C161798 subClassOf NCIT_C1909 @default.
- NCIT_C161798 subClassOf NCIT_C1967 @default.
- NCIT_C161798 subClassOf NCIT_C2189 @default.
- NCIT_C161798 subClassOf NCIT_C274 @default.
- NCIT_C161798 subClassOf NCIT_C308 @default.
- NCIT_C161798 subClassOf NCIT_C471 @default.