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- NCIT_C161831 IAO_0000115 "A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous PRAME-targeting TCR-engineered T-cells IMA203 specifically recognize and bind to PRAME expressed on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the PRAME-expressing cancer cells. PRAME is overexpressed by a variety of cancer cell types." @default.
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- NCIT_C161831 NCIT_P107 "Autologous PRAME-targeting TCR-engineered T-cells IMA203" @default.
- NCIT_C161831 NCIT_P108 "Autologous PRAME-targeting TCR-engineered T-cells IMA203" @default.
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- NCIT_C161831 hasExactSynonym "ACTengine IMA203" @default.
- NCIT_C161831 hasExactSynonym "Autologous PRAME-targeting TCR-engineered T-cells IMA203" @default.
- NCIT_C161831 hasExactSynonym "Autologous T-cell Receptor-engineered T-cells IMA203" @default.
- NCIT_C161831 hasExactSynonym "IMA 203" @default.
- NCIT_C161831 hasExactSynonym "IMA-203" @default.
- NCIT_C161831 hasExactSynonym "IMA203 Autologous T-lymphocytes" @default.
- NCIT_C161831 hasExactSynonym "IMA203 T-cells" @default.
- NCIT_C161831 hasExactSynonym "IMA203" @default.
- NCIT_C161831 inSubset NCIT_C116977 @default.
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- NCIT_C161831 type Class @default.
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- NCIT_C161831 label "Autologous PRAME-targeting TCR-engineered T-cells IMA203" @default.
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