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- NCIT_C162344 IAO_0000115 "A stilbenoid originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 (CA1) promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis; destruction of the tumor vasculature; disruption of tumor blood flow; and tumor cell necrosis. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production." @default.
- NCIT_C162344 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162344 NCIT_NHC0 "C162344" @default.
- NCIT_C162344 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162344 NCIT_P108 "Combretastatin A-1" @default.
- NCIT_C162344 NCIT_P175 "600032" @default.
- NCIT_C162344 NCIT_P208 "CL970855" @default.
- NCIT_C162344 NCIT_P210 "109971-63-3" @default.
- NCIT_C162344 NCIT_P319 "2222ATS339" @default.
- NCIT_C162344 NCIT_P322 "FDA" @default.
- NCIT_C162344 NCIT_P322 "GDC" @default.
- NCIT_C162344 NCIT_P375 "Combretastatin A-1" @default.
- NCIT_C162344 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162344 NCIT_R124 NCIT_C20480 @default.
- NCIT_C162344 NCIT_R124 NCIT_C40795 @default.
- NCIT_C162344 NCIT_R124 NCIT_C40798 @default.
- NCIT_C162344 normalizedInformationContent "100" @default.
- NCIT_C162344 referenceCount "1" @default.
- NCIT_C162344 hasExactSynonym "1,2-Benzenediol, 3-Methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethenyl)-, (Z)-" @default.
- NCIT_C162344 hasExactSynonym "CA1" @default.
- NCIT_C162344 hasExactSynonym "COMBRETASTATIN A-1" @default.
- NCIT_C162344 hasExactSynonym "Combretastatin A-1" @default.
- NCIT_C162344 hasExactSynonym "Combretastatin A1" @default.
- NCIT_C162344 inSubset NCIT_C128784 @default.
- NCIT_C162344 inSubset NCIT_C157711 @default.
- NCIT_C162344 inSubset NCIT_C157712 @default.
- NCIT_C162344 inSubset NCIT_C177537 @default.
- NCIT_C162344 inSubset NCIT_C63923 @default.
- NCIT_C162344 type Class @default.
- NCIT_C162344 isDefinedBy ncit.owl @default.
- NCIT_C162344 label "Combretastatin A-1" @default.
- NCIT_C162344 subClassOf NCIT_C162344 @default.
- NCIT_C162344 subClassOf NCIT_C186664 @default.
- NCIT_C162344 subClassOf NCIT_C1908 @default.
- NCIT_C162344 subClassOf NCIT_C1909 @default.
- NCIT_C162344 subClassOf NCIT_C25974 @default.
- NCIT_C162344 subClassOf NCIT_C273 @default.
- NCIT_C162344 subClassOf NCIT_C274 @default.
- NCIT_C162344 subClassOf NCIT_C67421 @default.