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- NCIT_C162375 IAO_0000115 "A competitive inhibitor for adenosine triphosphate (ATP) binding to polo-like kinase 1 (PLK1; PLK-1; STPK13), with potential antineoplastic activity. Upon administration, plogosertib selectively targets, binds to and inhibits PLK1, which disrupts mitosis and induces selective G2/M cell-cycle arrest followed by apoptosis in PLK1-overexpressing tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase that is crucial for the regulation of mitosis, and plays a key role in tumor cell proliferation, transformation and invasion. PLK1 expression is upregulated in a variety of tumor cell types and high expression is associated with increased aggressiveness and poor prognosis." @default.
- NCIT_C162375 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162375 NCIT_A7 NCIT_C17911 @default.
- NCIT_C162375 NCIT_NHC0 "C162375" @default.
- NCIT_C162375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162375 NCIT_P107 "PLK1 Inhibitor CYC140" @default.
- NCIT_C162375 NCIT_P108 "Plogosertib" @default.
- NCIT_C162375 NCIT_P208 "CL970820" @default.
- NCIT_C162375 NCIT_P210 "1137212-79-3" @default.
- NCIT_C162375 NCIT_P319 "IW5U2LC9XI" @default.
- NCIT_C162375 NCIT_P322 "CTRP" @default.
- NCIT_C162375 NCIT_P322 "FDA" @default.
- NCIT_C162375 NCIT_P322 "GDC" @default.
- NCIT_C162375 NCIT_P329 "798706" @default.
- NCIT_C162375 NCIT_P330 "798706" @default.
- NCIT_C162375 NCIT_P375 "PLK1 Inhibitor CYC140" @default.
- NCIT_C162375 NCIT_P399 "798706" @default.
- NCIT_C162375 normalizedInformationContent "100" @default.
- NCIT_C162375 referenceCount "1" @default.
- NCIT_C162375 hasExactSynonym "CYC 140" @default.
- NCIT_C162375 hasExactSynonym "CYC-140" @default.
- NCIT_C162375 hasExactSynonym "CYC140" @default.
- NCIT_C162375 hasExactSynonym "PLK-1 Inhibitor CYC140" @default.
- NCIT_C162375 hasExactSynonym "PLK1 Inhibitor CYC140" @default.
- NCIT_C162375 hasExactSynonym "PLOGOSERTIB" @default.
- NCIT_C162375 hasExactSynonym "Plogosertib" @default.
- NCIT_C162375 hasExactSynonym "Polo-like Kinase 1 Inhibitor CYC140" @default.
- NCIT_C162375 inSubset NCIT_C116977 @default.
- NCIT_C162375 inSubset NCIT_C116978 @default.
- NCIT_C162375 inSubset NCIT_C128784 @default.
- NCIT_C162375 inSubset NCIT_C157711 @default.
- NCIT_C162375 inSubset NCIT_C157712 @default.
- NCIT_C162375 inSubset NCIT_C176424 @default.
- NCIT_C162375 inSubset NCIT_C177537 @default.
- NCIT_C162375 inSubset NCIT_C63923 @default.
- NCIT_C162375 type Class @default.
- NCIT_C162375 isDefinedBy ncit.owl @default.
- NCIT_C162375 label "Plogosertib" @default.
- NCIT_C162375 subClassOf NCIT_C129824 @default.
- NCIT_C162375 subClassOf NCIT_C129825 @default.
- NCIT_C162375 subClassOf NCIT_C1404 @default.
- NCIT_C162375 subClassOf NCIT_C162375 @default.
- NCIT_C162375 subClassOf NCIT_C177899 @default.
- NCIT_C162375 subClassOf NCIT_C1908 @default.
- NCIT_C162375 subClassOf NCIT_C1909 @default.
- NCIT_C162375 subClassOf NCIT_C2189 @default.
- NCIT_C162375 subClassOf NCIT_C274 @default.
- NCIT_C162375 subClassOf NCIT_C471 @default.
- NCIT_C162375 subClassOf NCIT_C61074 @default.