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- NCIT_C16239 IAO_0000115 "Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth. Ligand binding increases ERBB2 tyrosine phosphorylation. A heterodimer with ERBB3 and ERBB4, p185ERBB2 is an essential component of the heregulin/neuregulin receptor. ERBB2 forms an IL6-dependent complex with IL6R gp130, resulting in ERBB2 tyrosine phosphorylation and MAPK activation. Oncogene ERBB2 disrupts normal cell function." @default.
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- NCIT_C16239 NCIT_P108 "Oncogene ErbB2" @default.
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- NCIT_C16239 hasExactSynonym "HER -2" @default.
- NCIT_C16239 hasExactSynonym "HER-2/NEU" @default.
- NCIT_C16239 hasExactSynonym "Oncogene ErbB2" @default.
- NCIT_C16239 hasExactSynonym "Oncogene, C-Erb -2" @default.
- NCIT_C16239 hasExactSynonym "Oncogene, C-ErbB-2" @default.
- NCIT_C16239 hasExactSynonym "Oncogene, ERBB2" @default.
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