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- NCIT_C162459 IAO_0000115 "A fusion protein composed of a human leukocyte antigen (HLA) complex, HLA-A*0201, with a peptide epitope derived from the human papillomavirus type 16 (HPV16) E7 protein (amino acid residues 11-20), a reduced affinity human interleukin-2 (IL-2) variant, and an effector attenuated human immunoglobulin G1 (IgG1) Fc domain, with potential antineoplastic and immunostimulatory activities. Upon administration, CUE-101 targets and selectively binds to E7-specific CD8-positive T-cells present in patients with HPV16-driven malignancies. This may induce the secretion of inflammatory cytokines such as interferon gamma (IFN gamma) and promote the activation and expansion of tumor-specific CD8-positive cells, which may lead to T-cell-mediated elimination of tumor cells expressing the HPV16 E7 antigen. The HPV16 E7 oncoprotein is a cell surface glycoprotein and tumor-associated antigen (TAA) that is overexpressed in various HPV-associated cancers." @default.
- NCIT_C162459 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162459 NCIT_A7 NCIT_C1179 @default.
- NCIT_C162459 NCIT_NHC0 "C162459" @default.
- NCIT_C162459 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162459 NCIT_P107 "HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101" @default.
- NCIT_C162459 NCIT_P108 "HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101" @default.
- NCIT_C162459 NCIT_P208 "CL970959" @default.
- NCIT_C162459 NCIT_P322 "CTRP" @default.
- NCIT_C162459 NCIT_P322 "GDC" @default.
- NCIT_C162459 NCIT_P329 "798742" @default.
- NCIT_C162459 NCIT_P375 "HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101" @default.
- NCIT_C162459 NCIT_P399 "798742" @default.
- NCIT_C162459 normalizedInformationContent "100" @default.
- NCIT_C162459 referenceCount "1" @default.
- NCIT_C162459 hasExactSynonym "Anti-HPV16 E7 Fusion Protein CUE-101" @default.
- NCIT_C162459 hasExactSynonym "CUE 101" @default.
- NCIT_C162459 hasExactSynonym "CUE-101" @default.
- NCIT_C162459 hasExactSynonym "CUE101" @default.
- NCIT_C162459 hasExactSynonym "HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101" @default.
- NCIT_C162459 inSubset NCIT_C116977 @default.
- NCIT_C162459 inSubset NCIT_C116978 @default.
- NCIT_C162459 inSubset NCIT_C128784 @default.
- NCIT_C162459 inSubset NCIT_C157711 @default.
- NCIT_C162459 inSubset NCIT_C157712 @default.
- NCIT_C162459 inSubset NCIT_C176424 @default.
- NCIT_C162459 inSubset NCIT_C177537 @default.
- NCIT_C162459 type Class @default.
- NCIT_C162459 isDefinedBy ncit.owl @default.
- NCIT_C162459 label "HPV16 E7-specific HLA-A*02:01-restricted IgG1-Fc Fusion Protein CUE-101" @default.
- NCIT_C162459 subClassOf NCIT_C1512 @default.
- NCIT_C162459 subClassOf NCIT_C162459 @default.
- NCIT_C162459 subClassOf NCIT_C1908 @default.
- NCIT_C162459 subClassOf NCIT_C1909 @default.
- NCIT_C162459 subClassOf NCIT_C307 @default.
- NCIT_C162459 subClassOf NCIT_C308 @default.