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- NCIT_C162480 IAO_0000115 "An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival." @default.
- NCIT_C162480 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162480 NCIT_A7 NCIT_C143021 @default.
- NCIT_C162480 NCIT_NHC0 "C162480" @default.
- NCIT_C162480 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162480 NCIT_P108 "MetAP2 Inhibitor APL-1202" @default.
- NCIT_C162480 NCIT_P208 "CL970968" @default.
- NCIT_C162480 NCIT_P322 "GDC" @default.
- NCIT_C162480 NCIT_P329 "798664" @default.
- NCIT_C162480 NCIT_P330 "798664" @default.
- NCIT_C162480 NCIT_P375 "MetAP2 Inhibitor APL-1202" @default.
- NCIT_C162480 NCIT_P399 "798664" @default.
- NCIT_C162480 normalizedInformationContent "100" @default.
- NCIT_C162480 referenceCount "1" @default.
- NCIT_C162480 hasExactSynonym "APL 1202" @default.
- NCIT_C162480 hasExactSynonym "APL-1202" @default.
- NCIT_C162480 hasExactSynonym "APL1202" @default.
- NCIT_C162480 hasExactSynonym "MetAP2 Inhibitor APL-1202" @default.
- NCIT_C162480 hasExactSynonym "Methionine Aminopeptidase Type II Inhibitor APL-1202" @default.
- NCIT_C162480 inSubset NCIT_C128784 @default.
- NCIT_C162480 inSubset NCIT_C157711 @default.
- NCIT_C162480 inSubset NCIT_C157712 @default.
- NCIT_C162480 inSubset NCIT_C176424 @default.
- NCIT_C162480 inSubset NCIT_C177537 @default.
- NCIT_C162480 type Class @default.
- NCIT_C162480 isDefinedBy ncit.owl @default.
- NCIT_C162480 label "MetAP2 Inhibitor APL-1202" @default.
- NCIT_C162480 subClassOf NCIT_C162480 @default.
- NCIT_C162480 subClassOf NCIT_C1908 @default.
- NCIT_C162480 subClassOf NCIT_C1909 @default.
- NCIT_C162480 subClassOf NCIT_C471 @default.
- NCIT_C162480 subClassOf NCIT_C783 @default.