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- NCIT_C162482 IAO_0000115 "A preparation of autologous T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous CD138 CAR-expressing T-cells target and induce selective toxicity in syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion." @default.
- NCIT_C162482 NCIT_NHC0 "C162482" @default.
- NCIT_C162482 NCIT_P106 "Cell" @default.
- NCIT_C162482 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162482 NCIT_P108 "Autologous CD138-specific CAR T-cells" @default.
- NCIT_C162482 NCIT_P208 "CL970980" @default.
- NCIT_C162482 NCIT_P329 "798661" @default.
- NCIT_C162482 NCIT_P330 "798661" @default.
- NCIT_C162482 NCIT_P399 "798661" @default.
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- NCIT_C162482 NCIT_R72 NCIT_C104083 @default.
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- NCIT_C162482 NCIT_R72 NCIT_C21599 @default.
- NCIT_C162482 NCIT_R72 NCIT_C32725 @default.
- NCIT_C162482 NCIT_R72 NCIT_C33061 @default.
- NCIT_C162482 NCIT_R72 NCIT_C38434 @default.
- NCIT_C162482 NCIT_R72 NCIT_C38439 @default.
- NCIT_C162482 NCIT_R72 NCIT_C39567 @default.
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- NCIT_C162482 normalizedInformationContent "100" @default.
- NCIT_C162482 referenceCount "1" @default.
- NCIT_C162482 hasExactSynonym "Autologous CD138-specific CAR T-cells" @default.
- NCIT_C162482 hasExactSynonym "Autologous CD138-specific CAR T-lymphocytes" @default.
- NCIT_C162482 hasExactSynonym "Autologous Syndecan-1-sepcific CAR T-cells" @default.
- NCIT_C162482 hasExactSynonym "Autologous Syndecan-1-specific CAR T-lymphocytes" @default.
- NCIT_C162482 inSubset NCIT_C128784 @default.
- NCIT_C162482 inSubset NCIT_C176424 @default.
- NCIT_C162482 type Class @default.
- NCIT_C162482 isDefinedBy ncit.owl @default.
- NCIT_C162482 label "Autologous CD138-specific CAR T-cells" @default.
- NCIT_C162482 subClassOf NCIT_C129820 @default.
- NCIT_C162482 subClassOf NCIT_C129821 @default.
- NCIT_C162482 subClassOf NCIT_C129826 @default.
- NCIT_C162482 subClassOf NCIT_C137999 @default.
- NCIT_C162482 subClassOf NCIT_C142078 @default.
- NCIT_C162482 subClassOf NCIT_C154231 @default.
- NCIT_C162482 subClassOf NCIT_C162482 @default.
- NCIT_C162482 subClassOf NCIT_C1908 @default.
- NCIT_C162482 subClassOf NCIT_C1909 @default.
- NCIT_C162482 subClassOf NCIT_C1962 @default.
- NCIT_C162482 subClassOf NCIT_C200766 @default.
- NCIT_C162482 subClassOf NCIT_C274 @default.
- NCIT_C162482 subClassOf NCIT_C28681 @default.
- NCIT_C162482 subClassOf NCIT_C307 @default.
- NCIT_C162482 subClassOf NCIT_C308 @default.