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- NCIT_C162521 IAO_0000115 "A human immunoglobulin G1 (IgG1) kappa monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS; CD278), with potential immunomodulating and antineoplastic activities. Upon administration, alomfilimab selectively binds to dimeric ICOS expressed on certain T-cells. This prevents the interaction between ICOS-positive T-cells and plasmacytoid dendritic cells (pDCs), which express the ICOS ligand (ICOSL). Blocking ICOS activation prevents the pDC-induced proliferation and accumulation of regulatory ICOS-positive T-cells (ICOS+ Tregs) and inhibits interleukin-10 (IL-10) secretion by CD4+ infiltrating T-cells. This may abrogate Treg-mediated immune suppression and may enhance cytotoxic T-lymphocyte (CTL)-mediated immune responses against tumor cells. Additionally, KY1044 may eliminate ICOS-positive T-cells via antibody-dependent cellular cytotoxicity (ADCC). ICOS, a T-cell specific, CD28-superfamily costimulatory molecule and immune checkpoint protein, plays a key role in the proliferation and activation of T-cells. It is normally expressed on both activated CD4+ T-cells, which is a subset of memory T-cells (Tm), and follicular helper T-cells (Tfh). ICOS is highly expressed on Tregs infiltrating various tumors and its expression is associated with a poor prognosis; ICOS-positive Tregs play a key role in immune suppression and tumor immune evasion." @default.
- NCIT_C162521 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162521 NCIT_A7 NCIT_C94803 @default.
- NCIT_C162521 NCIT_NHC0 "C162521" @default.
- NCIT_C162521 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C162521 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C162521 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162521 NCIT_P107 "Alomfilimab" @default.
- NCIT_C162521 NCIT_P108 "Alomfilimab" @default.
- NCIT_C162521 NCIT_P208 "CL970948" @default.
- NCIT_C162521 NCIT_P210 "2378692-24-9" @default.
- NCIT_C162521 NCIT_P319 "D2OPG50FF7" @default.
- NCIT_C162521 NCIT_P322 "CTRP" @default.
- NCIT_C162521 NCIT_P322 "FDA" @default.
- NCIT_C162521 NCIT_P322 "GDC" @default.
- NCIT_C162521 NCIT_P329 "798819" @default.
- NCIT_C162521 NCIT_P330 "798819" @default.
- NCIT_C162521 NCIT_P375 "Anti-ICOS Monoclonal Antibody KY1044" @default.
- NCIT_C162521 NCIT_P399 "798819" @default.
- NCIT_C162521 NCIT_R124 NCIT_C17710 @default.
- NCIT_C162521 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162521 NCIT_R124 NCIT_C18219 @default.
- NCIT_C162521 NCIT_R124 NCIT_C19986 @default.
- NCIT_C162521 NCIT_R124 NCIT_C40474 @default.
- NCIT_C162521 normalizedInformationContent "100" @default.
- NCIT_C162521 referenceCount "1" @default.
- NCIT_C162521 hasExactSynonym "ALOMFILIMAB" @default.
- NCIT_C162521 hasExactSynonym "Alomfilimab" @default.
- NCIT_C162521 hasExactSynonym "Anti-ICOS Monoclonal Antibody KY1044" @default.
- NCIT_C162521 hasExactSynonym "KY 1044" @default.
- NCIT_C162521 hasExactSynonym "KY-1044" @default.
- NCIT_C162521 hasExactSynonym "KY1044" @default.
- NCIT_C162521 inSubset NCIT_C116977 @default.
- NCIT_C162521 inSubset NCIT_C116978 @default.
- NCIT_C162521 inSubset NCIT_C128784 @default.
- NCIT_C162521 inSubset NCIT_C157711 @default.
- NCIT_C162521 inSubset NCIT_C157712 @default.
- NCIT_C162521 inSubset NCIT_C176424 @default.
- NCIT_C162521 inSubset NCIT_C177537 @default.
- NCIT_C162521 inSubset NCIT_C63923 @default.
- NCIT_C162521 type Class @default.
- NCIT_C162521 isDefinedBy ncit.owl @default.
- NCIT_C162521 label "Alomfilimab" @default.
- NCIT_C162521 subClassOf NCIT_C129821 @default.
- NCIT_C162521 subClassOf NCIT_C129822 @default.
- NCIT_C162521 subClassOf NCIT_C141144 @default.
- NCIT_C162521 subClassOf NCIT_C141145 @default.
- NCIT_C162521 subClassOf NCIT_C162521 @default.
- NCIT_C162521 subClassOf NCIT_C1908 @default.
- NCIT_C162521 subClassOf NCIT_C1909 @default.
- NCIT_C162521 subClassOf NCIT_C20401 @default.
- NCIT_C162521 subClassOf NCIT_C274 @default.
- NCIT_C162521 subClassOf NCIT_C307 @default.
- NCIT_C162521 subClassOf NCIT_C308 @default.