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- NCIT_C162525 IAO_0000115 "An orally bioavailable small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Upon oral administration, tubulin polymerization inhibitor AEZS 112 binds to tubulin and prevents its polymerization in tumor blood vessel endothelial cells and tumor cells. This blocks the formation of the mitotic spindle and leads to cell cycle arrest at the G2/M phase. As a result, this agent disrupts the tumor vasculature and tumor blood flow, deprives tumor cells of nutrients and induces tumor cell apoptosis. In addition, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization." @default.
- NCIT_C162525 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162525 NCIT_NHC0 "C162525" @default.
- NCIT_C162525 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162525 NCIT_P108 "Tubulin Polymerization Inhibitor AEZS 112" @default.
- NCIT_C162525 NCIT_P208 "CL971107" @default.
- NCIT_C162525 NCIT_P210 "1214741-69-1" @default.
- NCIT_C162525 NCIT_P322 "GDC" @default.
- NCIT_C162525 NCIT_P375 "Tubulin Polymerization Inhibitor AEZS 112" @default.
- NCIT_C162525 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162525 NCIT_R124 NCIT_C20480 @default.
- NCIT_C162525 NCIT_R124 NCIT_C40795 @default.
- NCIT_C162525 NCIT_R124 NCIT_C40798 @default.
- NCIT_C162525 normalizedInformationContent "100" @default.
- NCIT_C162525 referenceCount "1" @default.
- NCIT_C162525 hasExactSynonym "AEZS 112" @default.
- NCIT_C162525 hasExactSynonym "AEZS-112" @default.
- NCIT_C162525 hasExactSynonym "AEZS112" @default.
- NCIT_C162525 hasExactSynonym "Tubulin Polymerization Inhibitor AEZS 112" @default.
- NCIT_C162525 hasExactSynonym "ZEN 012" @default.
- NCIT_C162525 hasExactSynonym "ZEN-012" @default.
- NCIT_C162525 hasExactSynonym "ZEN012" @default.
- NCIT_C162525 inSubset NCIT_C128784 @default.
- NCIT_C162525 inSubset NCIT_C157711 @default.
- NCIT_C162525 inSubset NCIT_C157712 @default.
- NCIT_C162525 inSubset NCIT_C177537 @default.
- NCIT_C162525 type Class @default.
- NCIT_C162525 isDefinedBy ncit.owl @default.
- NCIT_C162525 label "Tubulin Polymerization Inhibitor AEZS 112" @default.
- NCIT_C162525 subClassOf NCIT_C162525 @default.
- NCIT_C162525 subClassOf NCIT_C186664 @default.
- NCIT_C162525 subClassOf NCIT_C1908 @default.
- NCIT_C162525 subClassOf NCIT_C1909 @default.
- NCIT_C162525 subClassOf NCIT_C25974 @default.
- NCIT_C162525 subClassOf NCIT_C273 @default.
- NCIT_C162525 subClassOf NCIT_C274 @default.