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- NCIT_C162528 IAO_0000115 "An antibody-drug conjugate (ADC) comprised of an anti-human B-cell maturation antigen (BCMA) immunoglobulin G1 (IgG1) antibody conjugated via the noncleavable linker 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (MCC), to the cytotoxic maytansine-derivative, DM1, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of AMG 224 selectively binds to BCMA expressed on the surface of tumor cells. Upon internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting both cell division and proliferation of tumor cells that express BCMA. BCMA, a receptor for a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF)and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells." @default.
- NCIT_C162528 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162528 NCIT_A7 NCIT_C97848 @default.
- NCIT_C162528 NCIT_NHC0 "C162528" @default.
- NCIT_C162528 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162528 NCIT_P107 "Anti-BCMA Antibody-drug Conjugate AMG 224" @default.
- NCIT_C162528 NCIT_P108 "Anti-BCMA Antibody-drug Conjugate AMG 224" @default.
- NCIT_C162528 NCIT_P208 "CL971104" @default.
- NCIT_C162528 NCIT_P319 "Y69B45U0TK" @default.
- NCIT_C162528 NCIT_P322 "CTRP" @default.
- NCIT_C162528 NCIT_P322 "FDA" @default.
- NCIT_C162528 NCIT_P322 "GDC" @default.
- NCIT_C162528 NCIT_P375 "Anti-BCMA Antibody-drug Conjugate AMG 224" @default.
- NCIT_C162528 normalizedInformationContent "100" @default.
- NCIT_C162528 referenceCount "1" @default.
- NCIT_C162528 hasExactSynonym "AMG 224" @default.
- NCIT_C162528 hasExactSynonym "AMG-224" @default.
- NCIT_C162528 hasExactSynonym "AMG224" @default.
- NCIT_C162528 hasExactSynonym "Anti-BCMA Antibody-drug Conjugate AMG 224" @default.
- NCIT_C162528 inSubset NCIT_C116977 @default.
- NCIT_C162528 inSubset NCIT_C116978 @default.
- NCIT_C162528 inSubset NCIT_C128784 @default.
- NCIT_C162528 inSubset NCIT_C157711 @default.
- NCIT_C162528 inSubset NCIT_C157712 @default.
- NCIT_C162528 inSubset NCIT_C177537 @default.
- NCIT_C162528 inSubset NCIT_C63923 @default.
- NCIT_C162528 type Class @default.
- NCIT_C162528 isDefinedBy ncit.owl @default.
- NCIT_C162528 label "Anti-BCMA Antibody-drug Conjugate AMG 224" @default.
- NCIT_C162528 subClassOf NCIT_C129821 @default.
- NCIT_C162528 subClassOf NCIT_C129823 @default.
- NCIT_C162528 subClassOf NCIT_C1512 @default.
- NCIT_C162528 subClassOf NCIT_C162528 @default.
- NCIT_C162528 subClassOf NCIT_C163758 @default.
- NCIT_C162528 subClassOf NCIT_C181108 @default.
- NCIT_C162528 subClassOf NCIT_C181111 @default.
- NCIT_C162528 subClassOf NCIT_C1908 @default.
- NCIT_C162528 subClassOf NCIT_C1909 @default.
- NCIT_C162528 subClassOf NCIT_C274 @default.
- NCIT_C162528 subClassOf NCIT_C307 @default.
- NCIT_C162528 subClassOf NCIT_C308 @default.