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- NCIT_C162537 IAO_0000115 "A recombinant fusion protein comprised of hu14.18, a humanized immunoglobulin G1 (IgG1) chimeric monoclonal antibody directed against the surface disialoganglioside GD2, fused to two human pro-inflammatory cytokine interleukin (IL)-2 molecules, with potential antineoplastic and immunomodulatory activities. Upon intravenous administration, the antibody moiety of lorukafusp alfa specifically targets and binds to GD2 expressed on certain tumor cells. This may stimulate the activation of immune effector cells including natural killer (NK) and T-cells, leading to tumor cell death via antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and GD2-specifc T-cell responses. By delivering IL-2 directly to the tumor microenvironment (TME), IL-2 is able to further stimulate NK and T-cell antitumor cellular immune responses locally. The glycosphingolipid GD2 is a tumor-associated antigen (TAA) overexpressed on the surface of many tumor cells." @default.
- NCIT_C162537 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162537 NCIT_A7 NCIT_C1110 @default.
- NCIT_C162537 NCIT_NHC0 "C162537" @default.
- NCIT_C162537 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C162537 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162537 NCIT_P107 "Lorukafusp alfa" @default.
- NCIT_C162537 NCIT_P108 "Lorukafusp alfa" @default.
- NCIT_C162537 NCIT_P175 "721298" @default.
- NCIT_C162537 NCIT_P208 "CL971111" @default.
- NCIT_C162537 NCIT_P210 "2131168-99-3" @default.
- NCIT_C162537 NCIT_P319 "PL21OR4LXE" @default.
- NCIT_C162537 NCIT_P322 "CTRP" @default.
- NCIT_C162537 NCIT_P322 "FDA" @default.
- NCIT_C162537 NCIT_P322 "GDC" @default.
- NCIT_C162537 NCIT_P325 "An anticancer drug in which hu14.18, a monoclonal antibody, is combined with interleukin-2. The monoclonal antibody binds to the cancer cells and delivers IL-2, which stimulates the immune system to destroy the cancer cells." @default.
- NCIT_C162537 NCIT_P375 "Hu14.18-IL2 Fusion Protein EMD 273063" @default.
- NCIT_C162537 NCIT_P399 "43349" @default.
- NCIT_C162537 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C162537 NCIT_R72 NCIT_C12508 @default.
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- NCIT_C162537 NCIT_R72 NCIT_C12542 @default.
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- NCIT_C162537 NCIT_R72 NCIT_C21599 @default.
- NCIT_C162537 NCIT_R72 NCIT_C32725 @default.
- NCIT_C162537 NCIT_R72 NCIT_C33061 @default.
- NCIT_C162537 NCIT_R72 NCIT_C38434 @default.
- NCIT_C162537 NCIT_R72 NCIT_C38439 @default.
- NCIT_C162537 NCIT_R72 NCIT_C39567 @default.
- NCIT_C162537 NCIT_R72 NCIT_C39568 @default.
- NCIT_C162537 normalizedInformationContent "100" @default.
- NCIT_C162537 referenceCount "1" @default.
- NCIT_C162537 hasExactSynonym "APN 301" @default.
- NCIT_C162537 hasExactSynonym "APN-301" @default.
- NCIT_C162537 hasExactSynonym "APN301" @default.
- NCIT_C162537 hasExactSynonym "EMD 273063" @default.
- NCIT_C162537 hasExactSynonym "EMD-273063" @default.
- NCIT_C162537 hasExactSynonym "Hu 14.18/IL - 2 Fusion Protein" @default.
- NCIT_C162537 hasExactSynonym "Hu14.18-IL2 Fusion Protein EMD 273063" @default.
- NCIT_C162537 hasExactSynonym "Hu14.18-IL2" @default.
- NCIT_C162537 hasExactSynonym "LORUKAFUSP ALFA" @default.
- NCIT_C162537 hasExactSynonym "Lorukafusp alfa" @default.
- NCIT_C162537 hasExactSynonym "hu14.18-interleukin-2 fusion protein" @default.
- NCIT_C162537 inSubset NCIT_C116977 @default.
- NCIT_C162537 inSubset NCIT_C116978 @default.
- NCIT_C162537 inSubset NCIT_C128784 @default.
- NCIT_C162537 inSubset NCIT_C157711 @default.
- NCIT_C162537 inSubset NCIT_C157712 @default.
- NCIT_C162537 inSubset NCIT_C176424 @default.
- NCIT_C162537 inSubset NCIT_C177537 @default.
- NCIT_C162537 inSubset NCIT_C63923 @default.
- NCIT_C162537 type Class @default.
- NCIT_C162537 isDefinedBy ncit.owl @default.
- NCIT_C162537 label "Lorukafusp alfa" @default.
- NCIT_C162537 subClassOf B01f4ca38b593acd3a0f62b538892849d @default.
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- NCIT_C162537 subClassOf NCIT_C1908 @default.
- NCIT_C162537 subClassOf NCIT_C1909 @default.
- NCIT_C162537 subClassOf NCIT_C307 @default.
- NCIT_C162537 subClassOf NCIT_C308 @default.