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- NCIT_C162553 IAO_0000115 "A replication-deficient adenovirus type 5 (Ad5) with E1 and partial E3 deletions containing cDNA for the herpes simplex virus thymidine kinase (HSV-Tk), which, when administered in combination with ganciclovir (GCV), possesses potential antineoplastic activity. Following administration, transgene-expressing cells produce thymidine kinase, which phosphorylates GCV to ganciclovir triphosphate, a cytotoxic nucleotide analog that is incorporated into DNA resulting in chain termination and induction of apoptosis in rapidly dividing cells. This process spares normal neurons as they do not proliferate and are therefore not susceptible to the toxic effects of GCV metabolites." @default.
- NCIT_C162553 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162553 NCIT_NHC0 "C162553" @default.
- NCIT_C162553 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162553 NCIT_P108 "Sitimagene Ceradenovec" @default.
- NCIT_C162553 NCIT_P208 "CL971128" @default.
- NCIT_C162553 NCIT_P210 "898830-54-1" @default.
- NCIT_C162553 NCIT_P322 "GDC" @default.
- NCIT_C162553 NCIT_P375 "Sitimagene Ceradenovec" @default.
- NCIT_C162553 normalizedInformationContent "100" @default.
- NCIT_C162553 referenceCount "1" @default.
- NCIT_C162553 hasExactSynonym "EG 009" @default.
- NCIT_C162553 hasExactSynonym "EG-009" @default.
- NCIT_C162553 hasExactSynonym "EG009" @default.
- NCIT_C162553 hasExactSynonym "Sitimagene Ceradenovec" @default.
- NCIT_C162553 inSubset NCIT_C128784 @default.
- NCIT_C162553 inSubset NCIT_C157711 @default.
- NCIT_C162553 inSubset NCIT_C157712 @default.
- NCIT_C162553 inSubset NCIT_C177537 @default.
- NCIT_C162553 type Class @default.
- NCIT_C162553 isDefinedBy ncit.owl @default.
- NCIT_C162553 label "Sitimagene Ceradenovec" @default.
- NCIT_C162553 subClassOf NCIT_C129821 @default.
- NCIT_C162553 subClassOf NCIT_C162553 @default.
- NCIT_C162553 subClassOf NCIT_C1908 @default.
- NCIT_C162553 subClassOf NCIT_C1909 @default.
- NCIT_C162553 subClassOf NCIT_C1962 @default.
- NCIT_C162553 subClassOf NCIT_C274 @default.
- NCIT_C162553 subClassOf NCIT_C307 @default.
- NCIT_C162553 subClassOf NCIT_C61199 @default.