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- NCIT_C162555 IAO_0000115 "An orally available selective inhibitor of the delta form of phosphatidylinositol 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic activity. Upon oral administration, puquitinib selectively binds to the ATP-binding pocket of PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K-delta over-expressing tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects." @default.
- NCIT_C162555 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162555 NCIT_A7 NCIT_C17270 @default.
- NCIT_C162555 NCIT_NHC0 "C162555" @default.
- NCIT_C162555 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162555 NCIT_P108 "Puquitinib" @default.
- NCIT_C162555 NCIT_P208 "CL971126" @default.
- NCIT_C162555 NCIT_P210 "916890-10-3" @default.
- NCIT_C162555 NCIT_P319 "WFG29AB872" @default.
- NCIT_C162555 NCIT_P322 "FDA" @default.
- NCIT_C162555 NCIT_P322 "GDC" @default.
- NCIT_C162555 NCIT_P375 "Puquitinib" @default.
- NCIT_C162555 normalizedInformationContent "100" @default.
- NCIT_C162555 referenceCount "1" @default.
- NCIT_C162555 hasExactSynonym "PUQUITINIB" @default.
- NCIT_C162555 hasExactSynonym "Puquitinib" @default.
- NCIT_C162555 hasExactSynonym "XC-302 Free Base" @default.
- NCIT_C162555 inSubset NCIT_C128784 @default.
- NCIT_C162555 inSubset NCIT_C157711 @default.
- NCIT_C162555 inSubset NCIT_C157712 @default.
- NCIT_C162555 inSubset NCIT_C177537 @default.
- NCIT_C162555 inSubset NCIT_C63923 @default.
- NCIT_C162555 type Class @default.
- NCIT_C162555 isDefinedBy ncit.owl @default.
- NCIT_C162555 label "Puquitinib" @default.
- NCIT_C162555 subClassOf NCIT_C129824 @default.
- NCIT_C162555 subClassOf NCIT_C129825 @default.
- NCIT_C162555 subClassOf NCIT_C1404 @default.
- NCIT_C162555 subClassOf NCIT_C162555 @default.
- NCIT_C162555 subClassOf NCIT_C163758 @default.
- NCIT_C162555 subClassOf NCIT_C1742 @default.
- NCIT_C162555 subClassOf NCIT_C1908 @default.
- NCIT_C162555 subClassOf NCIT_C1909 @default.
- NCIT_C162555 subClassOf NCIT_C2152 @default.
- NCIT_C162555 subClassOf NCIT_C2189 @default.
- NCIT_C162555 subClassOf NCIT_C274 @default.
- NCIT_C162555 subClassOf NCIT_C471 @default.