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- NCIT_C162565 IAO_0000115 "A radioconjugate consisting of lilotomab, a murine immunoglobulin G1 (IgG1) antibody directed against the CD37 antigen, conjugated via the chelating agent 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic acid (p-SCN-Bn-DOTA) with potential antineoplastic activities. Upon administration of lutetium Lu 177 lilotomab-satetraxetan, the lilotomab moiety binds to CD37 expressed on certain tumor cells. Upon binding, lutetium Lu 177 lilotomab-satetraxetan delivers a cytotoxic dose of beta radiation to CD37-expressing cells. CD37 is a transmembrane glycoprotein expressed at high-levels on B-cells and to a lesser extent on T-cells and myeloid cells, and is frequently overexpressed in certain B-cell lymphomas." @default.
- NCIT_C162565 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162565 NCIT_NHC0 "C162565" @default.
- NCIT_C162565 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162565 NCIT_P108 "Lutetium Lu 177 Lilotomab-satetraxetan" @default.
- NCIT_C162565 NCIT_P208 "CL446324" @default.
- NCIT_C162565 NCIT_P210 "1453362-90-7" @default.
- NCIT_C162565 NCIT_P319 "054ZP16K2Q" @default.
- NCIT_C162565 NCIT_P322 "FDA" @default.
- NCIT_C162565 NCIT_P322 "GDC" @default.
- NCIT_C162565 NCIT_P375 "Lutetium Lu 177 Lilotomab-satetraxetan" @default.
- NCIT_C162565 normalizedInformationContent "100" @default.
- NCIT_C162565 referenceCount "1" @default.
- NCIT_C162565 hasExactSynonym "177Lu Lilotomab Satetraxetan" @default.
- NCIT_C162565 hasExactSynonym "177Lu-Lilotomab-satetraxetan" @default.
- NCIT_C162565 hasExactSynonym "Betalutin" @default.
- NCIT_C162565 hasExactSynonym "LUTETIUM (LU177) LILOTOMAB SATETRAXETAN" @default.
- NCIT_C162565 hasExactSynonym "Lutetium Lu 177 Lilotomab-satetraxetan" @default.
- NCIT_C162565 hasExactSynonym "Lutetium Lu-177 Lilotomab Satetraxetan" @default.
- NCIT_C162565 hasExactSynonym "Lutetium Lu-177 Lilotomab-satetraxetan" @default.
- NCIT_C162565 inSubset NCIT_C128784 @default.
- NCIT_C162565 inSubset NCIT_C157711 @default.
- NCIT_C162565 inSubset NCIT_C157712 @default.
- NCIT_C162565 inSubset NCIT_C177537 @default.
- NCIT_C162565 inSubset NCIT_C63923 @default.
- NCIT_C162565 type Class @default.
- NCIT_C162565 isDefinedBy ncit.owl @default.
- NCIT_C162565 label "Lutetium Lu 177 Lilotomab-satetraxetan" @default.
- NCIT_C162565 subClassOf NCIT_C129819 @default.
- NCIT_C162565 subClassOf NCIT_C1446 @default.
- NCIT_C162565 subClassOf NCIT_C1511 @default.
- NCIT_C162565 subClassOf NCIT_C1512 @default.
- NCIT_C162565 subClassOf NCIT_C162565 @default.
- NCIT_C162565 subClassOf NCIT_C1908 @default.
- NCIT_C162565 subClassOf NCIT_C1909 @default.
- NCIT_C162565 subClassOf NCIT_C2124 @default.
- NCIT_C162565 subClassOf NCIT_C274 @default.
- NCIT_C162565 subClassOf NCIT_C307 @default.
- NCIT_C162565 subClassOf NCIT_C308 @default.