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- NCIT_C162567 IAO_0000115 "The mesylate salt of luminespib, a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Upon administration, luminespib binds with high affinity to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines. Hsp90, a 90 kDa molecular chaperone, plays a key role in the conformational maturation, stability and function of other substrate or "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition." @default.
- NCIT_C162567 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162567 NCIT_A6 NCIT_C71467 @default.
- NCIT_C162567 NCIT_NHC0 "C162567" @default.
- NCIT_C162567 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162567 NCIT_P108 "Luminespib Mesylate" @default.
- NCIT_C162567 NCIT_P208 "CL971084" @default.
- NCIT_C162567 NCIT_P210 "1051919-26-6" @default.
- NCIT_C162567 NCIT_P319 "6R0MAC137G" @default.
- NCIT_C162567 NCIT_P322 "FDA" @default.
- NCIT_C162567 NCIT_P322 "GDC" @default.
- NCIT_C162567 NCIT_P375 "Luminespib Mesylate" @default.
- NCIT_C162567 NCIT_R125 NCIT_C17828 @default.
- NCIT_C162567 NCIT_R125 NCIT_C20150 @default.
- NCIT_C162567 NCIT_R125 NCIT_C20480 @default.
- NCIT_C162567 NCIT_R125 NCIT_C40715 @default.
- NCIT_C162567 NCIT_R125 NCIT_C41515 @default.
- NCIT_C162567 NCIT_R125 NCIT_C51037 @default.
- NCIT_C162567 normalizedInformationContent "100" @default.
- NCIT_C162567 referenceCount "1" @default.
- NCIT_C162567 hasExactSynonym "LUMINESPIB MESYLATE" @default.
- NCIT_C162567 hasExactSynonym "Luminespib Mesilate" @default.
- NCIT_C162567 hasExactSynonym "Luminespib Mesylate Hydrate" @default.
- NCIT_C162567 hasExactSynonym "Luminespib Mesylate" @default.
- NCIT_C162567 hasExactSynonym "NVP-AUY922-AGB" @default.
- NCIT_C162567 inSubset NCIT_C128784 @default.
- NCIT_C162567 inSubset NCIT_C157711 @default.
- NCIT_C162567 inSubset NCIT_C157712 @default.
- NCIT_C162567 inSubset NCIT_C177537 @default.
- NCIT_C162567 inSubset NCIT_C63923 @default.
- NCIT_C162567 type Class @default.
- NCIT_C162567 isDefinedBy ncit.owl @default.
- NCIT_C162567 label "Luminespib Mesylate" @default.
- NCIT_C162567 subClassOf B590afa36ef796bb0a7ce5f0733e4c6e5 @default.
- NCIT_C162567 subClassOf B89e174a02c4737c577220aa00b7b4b19 @default.
- NCIT_C162567 subClassOf NCIT_C129824 @default.
- NCIT_C162567 subClassOf NCIT_C156880 @default.
- NCIT_C162567 subClassOf NCIT_C162567 @default.
- NCIT_C162567 subClassOf NCIT_C1908 @default.
- NCIT_C162567 subClassOf NCIT_C1909 @default.
- NCIT_C162567 subClassOf NCIT_C2189 @default.
- NCIT_C162567 subClassOf NCIT_C274 @default.
- NCIT_C162567 subClassOf NCIT_C74526 @default.