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- NCIT_C162577 IAO_0000115 "An engineered Fc-based heterodimeric bispecific monoclonal antibody, derived from trastuzumab and pertuzumab, directed against two distinct epitopes of the extracellular dimerization domain of the tumor-associated antigen (TAA) human tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunomodulating and antineoplastic activities. Upon administration, anbenitamab simultaneously targets and binds to two separate, non-overlapping epitopes of HER-2, thereby inhibiting HER-2 heterodimerization and prevents the activation of HER-2 signaling pathways. By binding to HER-2, KN026 induces an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress HER-2. This results in tumor cell apoptosis and inhibits tumor cell proliferation of HER-2-overexpressing tumor cells. HER-2, overexpressed on a variety of tumor cell types, plays an important role in proliferation, differentiation and survival." @default.
- NCIT_C162577 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162577 NCIT_A7 NCIT_C17319 @default.
- NCIT_C162577 NCIT_NHC0 "C162577" @default.
- NCIT_C162577 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162577 NCIT_P107 "Anbenitamab" @default.
- NCIT_C162577 NCIT_P108 "Anbenitamab" @default.
- NCIT_C162577 NCIT_P208 "CL971091" @default.
- NCIT_C162577 NCIT_P210 "2367012-88-0" @default.
- NCIT_C162577 NCIT_P319 "RHS90QRF9E" @default.
- NCIT_C162577 NCIT_P322 "CTRP" @default.
- NCIT_C162577 NCIT_P322 "FDA" @default.
- NCIT_C162577 NCIT_P322 "GDC" @default.
- NCIT_C162577 NCIT_P329 "798820" @default.
- NCIT_C162577 NCIT_P330 "798820" @default.
- NCIT_C162577 NCIT_P375 "Anti-HER-2 Bispecific Antibody KN026" @default.
- NCIT_C162577 NCIT_P399 "798820" @default.
- NCIT_C162577 NCIT_R124 NCIT_C17710 @default.
- NCIT_C162577 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162577 NCIT_R124 NCIT_C18219 @default.
- NCIT_C162577 NCIT_R124 NCIT_C19986 @default.
- NCIT_C162577 NCIT_R124 NCIT_C40474 @default.
- NCIT_C162577 normalizedInformationContent "100" @default.
- NCIT_C162577 referenceCount "1" @default.
- NCIT_C162577 hasExactSynonym "ANBENITAMAB" @default.
- NCIT_C162577 hasExactSynonym "Anbenitamab" @default.
- NCIT_C162577 hasExactSynonym "Anti-HER-2 Bispecific Antibody KN026" @default.
- NCIT_C162577 hasExactSynonym "Anti-HER2 Heterodimeric Antibody KN026" @default.
- NCIT_C162577 hasExactSynonym "HER2 Bispecific Antibody KN026" @default.
- NCIT_C162577 hasExactSynonym "KN 026" @default.
- NCIT_C162577 hasExactSynonym "KN-026" @default.
- NCIT_C162577 hasExactSynonym "KN026" @default.
- NCIT_C162577 inSubset NCIT_C116977 @default.
- NCIT_C162577 inSubset NCIT_C116978 @default.
- NCIT_C162577 inSubset NCIT_C128784 @default.
- NCIT_C162577 inSubset NCIT_C157711 @default.
- NCIT_C162577 inSubset NCIT_C157712 @default.
- NCIT_C162577 inSubset NCIT_C176424 @default.
- NCIT_C162577 inSubset NCIT_C177537 @default.
- NCIT_C162577 inSubset NCIT_C63923 @default.
- NCIT_C162577 type Class @default.
- NCIT_C162577 isDefinedBy ncit.owl @default.
- NCIT_C162577 label "Anbenitamab" @default.
- NCIT_C162577 subClassOf NCIT_C129821 @default.
- NCIT_C162577 subClassOf NCIT_C129822 @default.
- NCIT_C162577 subClassOf NCIT_C1454 @default.
- NCIT_C162577 subClassOf NCIT_C155711 @default.
- NCIT_C162577 subClassOf NCIT_C162577 @default.
- NCIT_C162577 subClassOf NCIT_C163758 @default.
- NCIT_C162577 subClassOf NCIT_C163760 @default.
- NCIT_C162577 subClassOf NCIT_C1908 @default.
- NCIT_C162577 subClassOf NCIT_C1909 @default.
- NCIT_C162577 subClassOf NCIT_C20401 @default.
- NCIT_C162577 subClassOf NCIT_C274 @default.
- NCIT_C162577 subClassOf NCIT_C28227 @default.
- NCIT_C162577 subClassOf NCIT_C307 @default.
- NCIT_C162577 subClassOf NCIT_C308 @default.