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- NCIT_C162645 IAO_0000115 "A pegylated recombinant, engineered variant of cytokine interleukin-2 (IL-2; IL2) where novel amino acid is encoded in the IL-2 gene that is leveraged for use in site-specific pegylation, with potential immunostimulating activity. Upon administration of pegenzileukin, the IL-2 variant moiety binds to dimers containing the IL-2 receptor beta and gamma chains (IL2Rbg; IL2Rbetagamma) on immune cells, such as cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, thereby activating these cells and inducing their expansion. It also induces the expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses against tumor cells causes tumor cell destruction. The addition of the novel amino acid and the concurrent pegylation prevents the binding of the IL-2 moiety to the IL-2 receptor alpha chain (IL2Ra), thereby blocking the IL2Ra-mediated activation of CD4-positive regulatory and immunosuppressive T-cells (Tregs). Since it cannot bind to IL2Ra expressed on innate lymphoid cells in the vascular endothelium, pegenzileukin prevents IL-2-mediated recruitment and activation of eosinophils, and inhibits the induction of eosinophil-mediated vascular leak syndrome (VLS). Pegylation also extends the half-life of pegenzileukin. Compared to recombinant IL-2, pegenzileukin allows for increased IL-2Rbg binding and proliferation of CTLs without stimulating the toxicity caused by binding to IL-2Ra." @default.
- NCIT_C162645 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162645 NCIT_NHC0 "C162645" @default.
- NCIT_C162645 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C162645 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C162645 NCIT_P107 "Pegenzileukin" @default.
- NCIT_C162645 NCIT_P108 "Pegenzileukin" @default.
- NCIT_C162645 NCIT_P208 "CL971032" @default.
- NCIT_C162645 NCIT_P210 "2573074-47-0" @default.
- NCIT_C162645 NCIT_P319 "10WR240QN7" @default.
- NCIT_C162645 NCIT_P322 "CTRP" @default.
- NCIT_C162645 NCIT_P322 "FDA" @default.
- NCIT_C162645 NCIT_P322 "GDC" @default.
- NCIT_C162645 NCIT_P329 "798926" @default.
- NCIT_C162645 NCIT_P330 "798926" @default.
- NCIT_C162645 NCIT_P375 "Pegylated Recombinant Interleukin-2 THOR-707" @default.
- NCIT_C162645 NCIT_P399 "798926" @default.
- NCIT_C162645 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C162645 NCIT_R146 NCIT_C104679 @default.
- NCIT_C162645 NCIT_R146 NCIT_C21176 @default.
- NCIT_C162645 NCIT_R146 NCIT_C26548 @default.
- NCIT_C162645 normalizedInformationContent "100" @default.
- NCIT_C162645 referenceCount "1" @default.
- NCIT_C162645 hasExactSynonym "IL-2 Variant THOR-707" @default.
- NCIT_C162645 hasExactSynonym "PEGENZILEUKIN" @default.
- NCIT_C162645 hasExactSynonym "Pegenzileukin" @default.
- NCIT_C162645 hasExactSynonym "Pegylated Recombinant IL-2 Variant THOR-707" @default.
- NCIT_C162645 hasExactSynonym "Pegylated Recombinant Interleukin-2 THOR-707" @default.
- NCIT_C162645 hasExactSynonym "SAR 444245" @default.
- NCIT_C162645 hasExactSynonym "SAR-444245" @default.
- NCIT_C162645 hasExactSynonym "SAR444245" @default.
- NCIT_C162645 hasExactSynonym "THOR 707" @default.
- NCIT_C162645 hasExactSynonym "THOR-707" @default.
- NCIT_C162645 hasExactSynonym "THOR707" @default.
- NCIT_C162645 inSubset NCIT_C116977 @default.
- NCIT_C162645 inSubset NCIT_C116978 @default.
- NCIT_C162645 inSubset NCIT_C128784 @default.
- NCIT_C162645 inSubset NCIT_C157711 @default.
- NCIT_C162645 inSubset NCIT_C157712 @default.
- NCIT_C162645 inSubset NCIT_C176424 @default.
- NCIT_C162645 inSubset NCIT_C177537 @default.
- NCIT_C162645 inSubset NCIT_C63923 @default.
- NCIT_C162645 type Class @default.
- NCIT_C162645 isDefinedBy ncit.owl @default.
- NCIT_C162645 label "Pegenzileukin" @default.
- NCIT_C162645 subClassOf NCIT_C1283 @default.
- NCIT_C162645 subClassOf NCIT_C162645 @default.
- NCIT_C162645 subClassOf NCIT_C1908 @default.
- NCIT_C162645 subClassOf NCIT_C1909 @default.
- NCIT_C162645 subClassOf NCIT_C307 @default.
- NCIT_C162645 subClassOf NCIT_C308 @default.
- NCIT_C162645 subClassOf NCIT_C587 @default.
- NCIT_C162645 subClassOf NCIT_C593 @default.