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- NCIT_C162649 IAO_0000115 "An engineered toxin body (ETB) composed of a single chain variable fragment (scFv) from an antibody targeting the human epidermal growth factor receptor 2 (HER2; HER-2), fused to the enzymatically active de-immunized, ribosome-inactivating cytotoxic payload Shiga-like toxin-A subunit (SLTA), with potential antineoplastic activity. Upon administration, the scFv moiety of MT-5111 specifically targets and binds to a distinct epitope on HER2-expressing cells. Upon internalization, the SLTA moiety is released and acts as an N-glycosidase, which binds to and cleaves an adenine nucleobase in the 28S RNA component of the 60S subunit of ribosomes and prevents ribosome activity. This inhibits protein synthesis and leads to apoptosis in HER2-expressing tumor cells. HER2, a tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types." @default.
- NCIT_C162649 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162649 NCIT_A7 NCIT_C17319 @default.
- NCIT_C162649 NCIT_NHC0 "C162649" @default.
- NCIT_C162649 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162649 NCIT_P107 "Engineered Toxin Body Targeting HER2 MT-5111" @default.
- NCIT_C162649 NCIT_P108 "Engineered Toxin Body Targeting HER2 MT-5111" @default.
- NCIT_C162649 NCIT_P208 "CL971043" @default.
- NCIT_C162649 NCIT_P322 "CTRP" @default.
- NCIT_C162649 NCIT_P322 "GDC" @default.
- NCIT_C162649 NCIT_P329 "798930" @default.
- NCIT_C162649 NCIT_P330 "798930" @default.
- NCIT_C162649 NCIT_P375 "Engineered Toxin Body Targeting HER2 MT-5111" @default.
- NCIT_C162649 NCIT_P399 "798930" @default.
- NCIT_C162649 normalizedInformationContent "100" @default.
- NCIT_C162649 referenceCount "1" @default.
- NCIT_C162649 hasExactSynonym "ETB Targeting HER2 MT-5111" @default.
- NCIT_C162649 hasExactSynonym "Engineered Toxin Body Targeting HER2 MT-5111" @default.
- NCIT_C162649 hasExactSynonym "HER2-targeted ETB MT-5111" @default.
- NCIT_C162649 hasExactSynonym "Immunotoxin MT-5111" @default.
- NCIT_C162649 hasExactSynonym "MT 5111" @default.
- NCIT_C162649 hasExactSynonym "MT-5111" @default.
- NCIT_C162649 hasExactSynonym "MT5111" @default.
- NCIT_C162649 hasExactSynonym "Recombinant Fusion Protein MT-5111" @default.
- NCIT_C162649 hasExactSynonym "Targeted Engineered Toxin Body MT-5111" @default.
- NCIT_C162649 inSubset NCIT_C116977 @default.
- NCIT_C162649 inSubset NCIT_C116978 @default.
- NCIT_C162649 inSubset NCIT_C128784 @default.
- NCIT_C162649 inSubset NCIT_C157711 @default.
- NCIT_C162649 inSubset NCIT_C157712 @default.
- NCIT_C162649 inSubset NCIT_C176424 @default.
- NCIT_C162649 inSubset NCIT_C177537 @default.
- NCIT_C162649 type Class @default.
- NCIT_C162649 isDefinedBy ncit.owl @default.
- NCIT_C162649 label "Engineered Toxin Body Targeting HER2 MT-5111" @default.
- NCIT_C162649 subClassOf NCIT_C1512 @default.
- NCIT_C162649 subClassOf NCIT_C162649 @default.
- NCIT_C162649 subClassOf NCIT_C1908 @default.
- NCIT_C162649 subClassOf NCIT_C1909 @default.
- NCIT_C162649 subClassOf NCIT_C307 @default.
- NCIT_C162649 subClassOf NCIT_C308 @default.
- NCIT_C162649 subClassOf NCIT_C575 @default.