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- NCIT_C162757 IAO_0000115 "An inhalation solution composed of a fixed combination of the dipropionate salt form of the synthetic glucocorticoid beclomethasone and the fumarate salt form of the long-acting and selective sympathomimetic beta-receptor agonist formoterol, with anti-inflammatory and bronchial smooth muscle-relaxing activities. Upon pressurized inhalation of the beclomethasone/formoterol solution, beclomethasone binds to intracellular glucocorticoid receptors (GRs), exhibiting inhibitory activities against multiple cell types and mediators associated with allergic inflammation. Formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, activating intracellular adenylyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cAMP). Increased intracellular cAMP results in the relaxation of bronchial smooth muscle and inhibition of the cellular release of mediators of immediate hypersensitivity, especially from mast cells. This may improve lung function." @default.
- NCIT_C162757 NCIT_NHC0 "C162757" @default.
- NCIT_C162757 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162757 NCIT_P108 "Beclomethasone Dipropionate/Formoterol Fumarate Inhalation Solution" @default.
- NCIT_C162757 NCIT_P208 "CL973186" @default.
- NCIT_C162757 normalizedInformationContent "100" @default.
- NCIT_C162757 referenceCount "1" @default.
- NCIT_C162757 hasExactSynonym "Beclomethasone Dipropionate/Formoterol Fumarate Inhalation Solution" @default.
- NCIT_C162757 hasExactSynonym "Beclomethasone/Formoterol Inhalation Solution" @default.
- NCIT_C162757 hasExactSynonym "Fostair Inhalation Solution" @default.
- NCIT_C162757 type Class @default.
- NCIT_C162757 isDefinedBy ncit.owl @default.
- NCIT_C162757 label "Beclomethasone Dipropionate/Formoterol Fumarate Inhalation Solution" @default.
- NCIT_C162757 subClassOf NCIT_C162757 @default.
- NCIT_C162757 subClassOf NCIT_C1908 @default.
- NCIT_C162757 subClassOf NCIT_C1909 @default.
- NCIT_C162757 subClassOf NCIT_C29712 @default.
- NCIT_C162757 subClassOf NCIT_C78273 @default.