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- NCIT_C162774 IAO_0000115 "A mixture of the two engineered monoclonal antibodies iparomlimab, which is an immunoglobulin G4 (IgG4) monoclonal antibody directed against the human negative immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and tuvonralimab, which is an IgG1 monoclonal antibody directed against the cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration of iparomlimab/tuvonralimab, iparomlimab and tuvonralimab target and bind to PD-1 and CTLA4 expressed on tumor-infiltrating lymphocytes (TILs), respectively. This inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD-1 and CTLA4 enhances T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone." @default.
- NCIT_C162774 NCIT_A7 NCIT_C17489 @default.
- NCIT_C162774 NCIT_NHC0 "C162774" @default.
- NCIT_C162774 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162774 NCIT_P107 "Iparomlimab/Tuvonralimab" @default.
- NCIT_C162774 NCIT_P108 "Iparomlimab/Tuvonralimab" @default.
- NCIT_C162774 NCIT_P208 "CL973202" @default.
- NCIT_C162774 NCIT_P322 "CTRP" @default.
- NCIT_C162774 NCIT_P329 "798992" @default.
- NCIT_C162774 NCIT_P330 "798992" @default.
- NCIT_C162774 NCIT_P399 "798992" @default.
- NCIT_C162774 NCIT_R124 NCIT_C17710 @default.
- NCIT_C162774 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162774 NCIT_R124 NCIT_C18219 @default.
- NCIT_C162774 NCIT_R124 NCIT_C19986 @default.
- NCIT_C162774 NCIT_R124 NCIT_C40474 @default.
- NCIT_C162774 normalizedInformationContent "100" @default.
- NCIT_C162774 referenceCount "1" @default.
- NCIT_C162774 hasExactSynonym "Anti-PD-1/Anti-CTLA-4 Monoclonal Antibody Mixture PSB205" @default.
- NCIT_C162774 hasExactSynonym "Anti-PD-1/CTLA-4 MabPair PSB205" @default.
- NCIT_C162774 hasExactSynonym "Anti-PD1/Anti-CTLA4 Antibody Mixture PSB205" @default.
- NCIT_C162774 hasExactSynonym "Anti-PD1/Anti-CTLA4 Antibody Mixture QL1706" @default.
- NCIT_C162774 hasExactSynonym "Anti-PD1/CTLA4 Antibodies PSB205" @default.
- NCIT_C162774 hasExactSynonym "Bifunctional MabPair Product PSB205" @default.
- NCIT_C162774 hasExactSynonym "Iparomlimab/Tuvonralimab" @default.
- NCIT_C162774 hasExactSynonym "PSB 205" @default.
- NCIT_C162774 hasExactSynonym "PSB-205" @default.
- NCIT_C162774 hasExactSynonym "PSB205" @default.
- NCIT_C162774 hasExactSynonym "QL 1706" @default.
- NCIT_C162774 hasExactSynonym "QL-1706" @default.
- NCIT_C162774 hasExactSynonym "QL1706" @default.
- NCIT_C162774 inSubset NCIT_C116977 @default.
- NCIT_C162774 inSubset NCIT_C116978 @default.
- NCIT_C162774 inSubset NCIT_C128784 @default.
- NCIT_C162774 inSubset NCIT_C176424 @default.
- NCIT_C162774 type Class @default.
- NCIT_C162774 isDefinedBy ncit.owl @default.
- NCIT_C162774 label "Iparomlimab/Tuvonralimab" @default.
- NCIT_C162774 subClassOf NCIT_C128036 @default.
- NCIT_C162774 subClassOf NCIT_C129821 @default.
- NCIT_C162774 subClassOf NCIT_C129822 @default.
- NCIT_C162774 subClassOf NCIT_C141144 @default.
- NCIT_C162774 subClassOf NCIT_C143250 @default.
- NCIT_C162774 subClassOf NCIT_C162774 @default.
- NCIT_C162774 subClassOf NCIT_C163758 @default.
- NCIT_C162774 subClassOf NCIT_C1908 @default.
- NCIT_C162774 subClassOf NCIT_C1909 @default.
- NCIT_C162774 subClassOf NCIT_C191738 @default.
- NCIT_C162774 subClassOf NCIT_C20401 @default.
- NCIT_C162774 subClassOf NCIT_C274 @default.
- NCIT_C162774 subClassOf NCIT_C307 @default.
- NCIT_C162774 subClassOf NCIT_C308 @default.