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- NCIT_C162807 IAO_0000115 "An antisense oligonucleotide targeting the growth hormone receptor (GHR; somatotropin receptor) mRNA, with potential somatotropin-inhibiting activity. Upon subcutaneous administration, cimdelirsen hybridizes with GHR mRNA, which blocks translation of the GHR protein. Reduction of GHR levels in turn decreases the circulating level of insulin-like growth factor-1 (IGF-1). IGF-1 is a hormone that plays an important role in childhood growth and has anabolic effects in adults. Excess production of IGF-1 results in various disease states including acromegaly." @default.
- NCIT_C162807 NCIT_A7 NCIT_C41017 @default.
- NCIT_C162807 NCIT_NHC0 "C162807" @default.
- NCIT_C162807 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C162807 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162807 NCIT_P107 "Cimdelirsen" @default.
- NCIT_C162807 NCIT_P108 "Cimdelirsen" @default.
- NCIT_C162807 NCIT_P208 "CL973173" @default.
- NCIT_C162807 NCIT_P210 "2131025-82-4" @default.
- NCIT_C162807 NCIT_P319 "F593G1C1YO" @default.
- NCIT_C162807 NCIT_P322 "CTRP" @default.
- NCIT_C162807 NCIT_P322 "FDA" @default.
- NCIT_C162807 NCIT_P329 "799097" @default.
- NCIT_C162807 NCIT_P330 "799097" @default.
- NCIT_C162807 NCIT_P399 "799097" @default.
- NCIT_C162807 normalizedInformationContent "100" @default.
- NCIT_C162807 referenceCount "1" @default.
- NCIT_C162807 hasExactSynonym "CIMDELIRSEN" @default.
- NCIT_C162807 hasExactSynonym "Cimdelirsen" @default.
- NCIT_C162807 hasExactSynonym "GHR Antisense Oligonucleotide IONIS-GHR-LRx" @default.
- NCIT_C162807 hasExactSynonym "Growth Hormone Receptor Antisense Oligonucleotide IONIS-GHR-LRx" @default.
- NCIT_C162807 hasExactSynonym "IONIS GHR LRX" @default.
- NCIT_C162807 hasExactSynonym "IONIS-GHR-LRx" @default.
- NCIT_C162807 hasExactSynonym "ISIS-766720" @default.
- NCIT_C162807 hasExactSynonym "LICA Drug IONIS-GHR-LRx" @default.
- NCIT_C162807 hasExactSynonym "Ligand-conjugated Antisense Drug IONIS-GHR-LRx" @default.
- NCIT_C162807 inSubset NCIT_C116977 @default.
- NCIT_C162807 inSubset NCIT_C116978 @default.
- NCIT_C162807 inSubset NCIT_C176424 @default.
- NCIT_C162807 inSubset NCIT_C63923 @default.
- NCIT_C162807 type Class @default.
- NCIT_C162807 isDefinedBy ncit.owl @default.
- NCIT_C162807 label "Cimdelirsen" @default.
- NCIT_C162807 subClassOf NCIT_C1291 @default.
- NCIT_C162807 subClassOf NCIT_C162807 @default.
- NCIT_C162807 subClassOf NCIT_C1908 @default.
- NCIT_C162807 subClassOf NCIT_C1909 @default.
- NCIT_C162807 subClassOf NCIT_C1962 @default.
- NCIT_C162807 subClassOf NCIT_C307 @default.