Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C162858> ?p ?o ?g. }
Showing items 1 to 38 of
38
with 100 items per page.
- NCIT_C162858 IAO_0000115 "An inhibitor of both the enzymes indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1) and tryptophan 2,3-dioxygenase 2 (TDO2; TDO-2), with potential immunomodulating and antineoplastic activities. Upon administration, IDO1/TDO2 inhibitor DN1406131 targets, binds to and inhibits both IDO1 and TDO2, which catalyze the first and rate-limiting step in the production of the immunosuppressive transcription factor aryl hydrocarbon receptor (AhR) ligand kynurenine (KYN). This inhibits the IDO1/TDO2-KYN-AhR pathway. Abrogation of AhR activation prevents the activation of immune-tolerant dendritic cells (DCs) and regulatory T-cells (Tregs) in the tumor microenvironment (TME). This may restore the immune response against tumor cells in which IDO1 and/or TDO2 are overexpressed. The IDO1/TDO2-KYN-AhR pathway is overexpressed in a variety of tumor cell types, plays a key role in immunosuppression and its expression is correlated with poor prognosis." @default.
- NCIT_C162858 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162858 NCIT_A7 NCIT_C17218 @default.
- NCIT_C162858 NCIT_A7 NCIT_C79782 @default.
- NCIT_C162858 NCIT_NHC0 "C162858" @default.
- NCIT_C162858 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162858 NCIT_P108 "IDO1/TDO2 Inhibitor DN1406131" @default.
- NCIT_C162858 NCIT_P208 "CL973340" @default.
- NCIT_C162858 NCIT_P322 "GDC" @default.
- NCIT_C162858 NCIT_P329 "798903" @default.
- NCIT_C162858 NCIT_P330 "798903" @default.
- NCIT_C162858 NCIT_P375 "IDO1/TDO2 Inhibitor DN1406131" @default.
- NCIT_C162858 NCIT_P399 "798903" @default.
- NCIT_C162858 normalizedInformationContent "100" @default.
- NCIT_C162858 referenceCount "1" @default.
- NCIT_C162858 hasExactSynonym "DN 1406131" @default.
- NCIT_C162858 hasExactSynonym "DN-1406131" @default.
- NCIT_C162858 hasExactSynonym "DN131" @default.
- NCIT_C162858 hasExactSynonym "DN1406131" @default.
- NCIT_C162858 hasExactSynonym "IDO1/TDO2 Inhibitor DN1406131" @default.
- NCIT_C162858 hasExactSynonym "Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase 2 Inhibitor DN1406131" @default.
- NCIT_C162858 inSubset NCIT_C128784 @default.
- NCIT_C162858 inSubset NCIT_C157711 @default.
- NCIT_C162858 inSubset NCIT_C157712 @default.
- NCIT_C162858 inSubset NCIT_C176424 @default.
- NCIT_C162858 inSubset NCIT_C177537 @default.
- NCIT_C162858 type Class @default.
- NCIT_C162858 isDefinedBy ncit.owl @default.
- NCIT_C162858 label "IDO1/TDO2 Inhibitor DN1406131" @default.
- NCIT_C162858 subClassOf NCIT_C129820 @default.
- NCIT_C162858 subClassOf NCIT_C141137 @default.
- NCIT_C162858 subClassOf NCIT_C141144 @default.
- NCIT_C162858 subClassOf NCIT_C162858 @default.
- NCIT_C162858 subClassOf NCIT_C1908 @default.
- NCIT_C162858 subClassOf NCIT_C1909 @default.
- NCIT_C162858 subClassOf NCIT_C274 @default.
- NCIT_C162858 subClassOf NCIT_C308 @default.
- NCIT_C162858 subClassOf NCIT_C471 @default.