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- NCIT_C162873 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) GD2, and the constitutively active interleukin 7 (IL-7) receptor (C7R), with potential antineoplastic activity. Upon intravenous administration, autologous active IL-7 receptor co-expressing GD2-specific CAR T-cells target, bind to, and induce selective toxicity in GD2-expressing tumor cells. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation, survival, and anti-tumor activity. GD2, a disialoganglioside and TAA, is overexpressed in a variety of tumor cell types." @default.
- NCIT_C162873 NCIT_NHC0 "C162873" @default.
- NCIT_C162873 NCIT_P106 "Cell" @default.
- NCIT_C162873 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162873 NCIT_P107 "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells" @default.
- NCIT_C162873 NCIT_P108 "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells" @default.
- NCIT_C162873 NCIT_P208 "CL973354" @default.
- NCIT_C162873 NCIT_P322 "CTRP" @default.
- NCIT_C162873 NCIT_P329 "798915" @default.
- NCIT_C162873 NCIT_P330 "798915" @default.
- NCIT_C162873 NCIT_P399 "798915" @default.
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- NCIT_C162873 normalizedInformationContent "100" @default.
- NCIT_C162873 referenceCount "1" @default.
- NCIT_C162873 hasExactSynonym "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells" @default.
- NCIT_C162873 hasExactSynonym "Autologous C7R-GD2.CART Cells" @default.
- NCIT_C162873 hasExactSynonym "Autologous T-lymphocytes Expressing GD2-specific Chimeric Antigen and Constitutively Active IL-7 Receptors" @default.
- NCIT_C162873 hasExactSynonym "Constitutively Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells" @default.
- NCIT_C162873 inSubset NCIT_C116977 @default.
- NCIT_C162873 inSubset NCIT_C116978 @default.
- NCIT_C162873 inSubset NCIT_C128784 @default.
- NCIT_C162873 inSubset NCIT_C176424 @default.
- NCIT_C162873 type Class @default.
- NCIT_C162873 isDefinedBy ncit.owl @default.
- NCIT_C162873 label "Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells" @default.
- NCIT_C162873 subClassOf NCIT_C129820 @default.
- NCIT_C162873 subClassOf NCIT_C129821 @default.
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- NCIT_C162873 subClassOf NCIT_C201491 @default.
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- NCIT_C162873 subClassOf NCIT_C28681 @default.
- NCIT_C162873 subClassOf NCIT_C307 @default.
- NCIT_C162873 subClassOf NCIT_C308 @default.