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- NCIT_C162875 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory activity. Upon administration, domvanalimab targets and binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating T-lymphocytes (TILs), thereby preventing the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, such as natural killer (NK) cells and CD8+ T-cells. This leads to CD226 dimerization and CD226-mediated signaling and activates the immune system to exert a T-cell-mediated immune response against cancer cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory receptor, plays a key role in the suppression of T-cell proliferation and activation; it is involved in tumor cell immune evasion, and the inhibition of antiviral immune responses." @default.
- NCIT_C162875 NCIT_A32 NCIT_C1909 @default.
- NCIT_C162875 NCIT_A7 NCIT_C126125 @default.
- NCIT_C162875 NCIT_NHC0 "C162875" @default.
- NCIT_C162875 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C162875 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162875 NCIT_P107 "Domvanalimab" @default.
- NCIT_C162875 NCIT_P108 "Domvanalimab" @default.
- NCIT_C162875 NCIT_P208 "CL973360" @default.
- NCIT_C162875 NCIT_P210 "2368219-35-4" @default.
- NCIT_C162875 NCIT_P319 "45X7OU8C4J" @default.
- NCIT_C162875 NCIT_P322 "CTRP" @default.
- NCIT_C162875 NCIT_P322 "FDA" @default.
- NCIT_C162875 NCIT_P322 "GDC" @default.
- NCIT_C162875 NCIT_P329 "798948" @default.
- NCIT_C162875 NCIT_P330 "798948" @default.
- NCIT_C162875 NCIT_P375 "Anti-TIGIT Monoclonal Antibody AB154" @default.
- NCIT_C162875 NCIT_P399 "798948" @default.
- NCIT_C162875 NCIT_R124 NCIT_C17710 @default.
- NCIT_C162875 NCIT_R124 NCIT_C17828 @default.
- NCIT_C162875 NCIT_R124 NCIT_C18219 @default.
- NCIT_C162875 NCIT_R124 NCIT_C19986 @default.
- NCIT_C162875 NCIT_R124 NCIT_C40474 @default.
- NCIT_C162875 normalizedInformationContent "100" @default.
- NCIT_C162875 referenceCount "1" @default.
- NCIT_C162875 hasExactSynonym "AB 154" @default.
- NCIT_C162875 hasExactSynonym "AB-154" @default.
- NCIT_C162875 hasExactSynonym "AB154" @default.
- NCIT_C162875 hasExactSynonym "Anti-TIGIT Monoclonal Antibody AB154" @default.
- NCIT_C162875 hasExactSynonym "DOMVANALIMAB" @default.
- NCIT_C162875 hasExactSynonym "Domvanalimab" @default.
- NCIT_C162875 inSubset NCIT_C116977 @default.
- NCIT_C162875 inSubset NCIT_C116978 @default.
- NCIT_C162875 inSubset NCIT_C128784 @default.
- NCIT_C162875 inSubset NCIT_C157711 @default.
- NCIT_C162875 inSubset NCIT_C157712 @default.
- NCIT_C162875 inSubset NCIT_C176424 @default.
- NCIT_C162875 inSubset NCIT_C177537 @default.
- NCIT_C162875 inSubset NCIT_C63923 @default.
- NCIT_C162875 type Class @default.
- NCIT_C162875 isDefinedBy ncit.owl @default.
- NCIT_C162875 label "Domvanalimab" @default.
- NCIT_C162875 subClassOf NCIT_C129821 @default.
- NCIT_C162875 subClassOf NCIT_C129822 @default.
- NCIT_C162875 subClassOf NCIT_C134787 @default.
- NCIT_C162875 subClassOf NCIT_C141144 @default.
- NCIT_C162875 subClassOf NCIT_C162875 @default.
- NCIT_C162875 subClassOf NCIT_C1908 @default.
- NCIT_C162875 subClassOf NCIT_C1909 @default.
- NCIT_C162875 subClassOf NCIT_C20401 @default.
- NCIT_C162875 subClassOf NCIT_C274 @default.
- NCIT_C162875 subClassOf NCIT_C307 @default.
- NCIT_C162875 subClassOf NCIT_C308 @default.