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- NCIT_C162883 IAO_0000115 "An injectable peptide mimetic of hepcidin (hepcidin antimicrobial peptide; HAMP; putative liver tumor regressor; PLTR; liver-expressed antimicrobial peptide 1; LEAP-1) with potential use in the treatment of iron deficiency anemia and iron overload secondary to hematologic disorders. Upon administration, rusfertide mimics endogenous hepcidin, a protein primarily produced in hepatocytes, and increases hepcidin levels. As hepcidin plays a key role in the homeostasis of systemic iron, rusfertide may serve to normalize iron levels. Low levels of endogenous hepcidin are associated with iron overload secondary to excessive absorption of iron as seen in beta thalassemia and paradoxically with iron deficiency anemia." @default.
- NCIT_C162883 NCIT_NHC0 "C162883" @default.
- NCIT_C162883 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C162883 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C162883 NCIT_P107 "Rusfertide" @default.
- NCIT_C162883 NCIT_P108 "Rusfertide" @default.
- NCIT_C162883 NCIT_P208 "CL973321" @default.
- NCIT_C162883 NCIT_P210 "1628323-80-7" @default.
- NCIT_C162883 NCIT_P319 "XM71MYX0IQ" @default.
- NCIT_C162883 NCIT_P322 "CTRP" @default.
- NCIT_C162883 NCIT_P322 "FDA" @default.
- NCIT_C162883 NCIT_P329 "799095" @default.
- NCIT_C162883 NCIT_P330 "799095" @default.
- NCIT_C162883 NCIT_P399 "799095" @default.
- NCIT_C162883 normalizedInformationContent "100" @default.
- NCIT_C162883 referenceCount "1" @default.
- NCIT_C162883 hasExactSynonym "Hepcidin Agonist PTG-300" @default.
- NCIT_C162883 hasExactSynonym "Hepcidin Mimetic PTG-300" @default.
- NCIT_C162883 hasExactSynonym "PTG 300" @default.
- NCIT_C162883 hasExactSynonym "PTG-300" @default.
- NCIT_C162883 hasExactSynonym "PTG300" @default.
- NCIT_C162883 hasExactSynonym "RUSFERTIDE" @default.
- NCIT_C162883 hasExactSynonym "Rusfertide" @default.
- NCIT_C162883 inSubset NCIT_C116977 @default.
- NCIT_C162883 inSubset NCIT_C116978 @default.
- NCIT_C162883 inSubset NCIT_C176424 @default.
- NCIT_C162883 inSubset NCIT_C63923 @default.
- NCIT_C162883 type Class @default.
- NCIT_C162883 isDefinedBy ncit.owl @default.
- NCIT_C162883 label "Rusfertide" @default.
- NCIT_C162883 subClassOf NCIT_C162883 @default.
- NCIT_C162883 subClassOf NCIT_C1908 @default.
- NCIT_C162883 subClassOf NCIT_C1909 @default.
- NCIT_C162883 subClassOf NCIT_C78275 @default.