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- NCIT_C1630 IAO_0000115 "A recombinant peptide, which is chemically identical or similar to the endogenous cytokine interleukin-14 (IL-14). The cytokine inhibits immunoglobulin secretion and selectively expands activated B-cell subpopulations. An IL-14 receptor is found on activated B-cells, but not in resting B-cells. This agent is unrelated to other cytokines but has homology with complement factor Bb. Autocrine or paracrine production of IL-14 may play a significant role in the rapid proliferation of aggressive non-Hodgkin lymphoma (NHL-B). Interrupting this pathway could be a useful goal of therapy for patients resistant to conventional chemotherapy." @default.
- NCIT_C1630 NCIT_NHC0 "C1630" @default.
- NCIT_C1630 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1630 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1630 NCIT_P108 "Recombinant Interleukin-14" @default.
- NCIT_C1630 NCIT_P207 "C1522568" @default.
- NCIT_C1630 NCIT_P366 "Therapeutic_Interleukin-14" @default.
- NCIT_C1630 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1630 NCIT_R125 NCIT_C18081 @default.
- NCIT_C1630 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1630 NCIT_R125 NCIT_C20751 @default.
- NCIT_C1630 normalizedInformationContent "100" @default.
- NCIT_C1630 referenceCount "1" @default.
- NCIT_C1630 hasExactSynonym "HMW-BCGF" @default.
- NCIT_C1630 hasExactSynonym "High Molecular Weight-B-Cell Growth Factor" @default.
- NCIT_C1630 hasExactSynonym "IL-14" @default.
- NCIT_C1630 hasExactSynonym "Interleukin 14" @default.
- NCIT_C1630 hasExactSynonym "Recombinant Interleukin-14" @default.
- NCIT_C1630 type Class @default.
- NCIT_C1630 isDefinedBy ncit.owl @default.
- NCIT_C1630 label "Recombinant Interleukin-14" @default.
- NCIT_C1630 subClassOf NCIT_C1283 @default.
- NCIT_C1630 subClassOf NCIT_C1630 @default.
- NCIT_C1630 subClassOf NCIT_C1908 @default.
- NCIT_C1630 subClassOf NCIT_C1909 @default.
- NCIT_C1630 subClassOf NCIT_C307 @default.
- NCIT_C1630 subClassOf NCIT_C308 @default.
- NCIT_C1630 subClassOf NCIT_C593 @default.