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- NCIT_C163023 IAO_0000115 "A cancer vaccine containing epidermal growth factor (EGF), with immunomodulating and antineoplastic activities. Upon administration of the EGF vaccine EGF-PTI, EGF induces an immune response against EGFR, which results in the formation of anti-EGF-specific neutralizing antibodies. This causes binding of the anti-EGF antibodies to endogenous EGF, reduces levels of circulating EGF and prevents the binding of EGF to its receptor EGFR. This prevents EGF/EGFR pathway activation and may result in an inhibition of proliferation in EGFR-overexpressing tumor cells. EGF/EGFR-mediated signaling is overactivated in certain cancer types and drives tumor cell proliferation and progression." @default.
- NCIT_C163023 NCIT_NHC0 "C163023" @default.
- NCIT_C163023 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163023 NCIT_P108 "EGF Vaccine EGF-PTI" @default.
- NCIT_C163023 NCIT_P208 "CL973373" @default.
- NCIT_C163023 NCIT_P329 "798974" @default.
- NCIT_C163023 NCIT_P330 "798974" @default.
- NCIT_C163023 NCIT_P399 "798974" @default.
- NCIT_C163023 NCIT_R124 NCIT_C17828 @default.
- NCIT_C163023 NCIT_R124 NCIT_C17930 @default.
- NCIT_C163023 NCIT_R124 NCIT_C17937 @default.
- NCIT_C163023 NCIT_R124 NCIT_C18839 @default.
- NCIT_C163023 NCIT_R124 NCIT_C21124 @default.
- NCIT_C163023 NCIT_R124 NCIT_C45548 @default.
- NCIT_C163023 normalizedInformationContent "100" @default.
- NCIT_C163023 referenceCount "1" @default.
- NCIT_C163023 hasExactSynonym "EGF Pathway Targeted Immunization Agent" @default.
- NCIT_C163023 hasExactSynonym "EGF Pathway Targeted Immunotherapy Agent" @default.
- NCIT_C163023 hasExactSynonym "EGF Pathway-targeted Immunotherapeutic" @default.
- NCIT_C163023 hasExactSynonym "EGF Vaccine EGF-PTI" @default.
- NCIT_C163023 hasExactSynonym "EGF-TPI" @default.
- NCIT_C163023 inSubset NCIT_C128784 @default.
- NCIT_C163023 inSubset NCIT_C176424 @default.
- NCIT_C163023 type Class @default.
- NCIT_C163023 isDefinedBy ncit.owl @default.
- NCIT_C163023 label "EGF Vaccine EGF-PTI" @default.
- NCIT_C163023 subClassOf NCIT_C129820 @default.
- NCIT_C163023 subClassOf NCIT_C163023 @default.
- NCIT_C163023 subClassOf NCIT_C1663 @default.
- NCIT_C163023 subClassOf NCIT_C1752 @default.
- NCIT_C163023 subClassOf NCIT_C1908 @default.
- NCIT_C163023 subClassOf NCIT_C1909 @default.
- NCIT_C163023 subClassOf NCIT_C274 @default.
- NCIT_C163023 subClassOf NCIT_C307 @default.
- NCIT_C163023 subClassOf NCIT_C308 @default.
- NCIT_C163023 subClassOf NCIT_C923 @default.