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- NCIT_C163758 IAO_0000115 "Any agent that specifically targets or interferes with the synthesis or function of a molecule that is expressed specifically in or on cells of the tumor and/or the tumor microenvironment (TME), such as immune cells or surrounding blood vessels. The targeted molecule is usually overexpressed or mutated in tumors but minimally or not expressed by normal, healthy tissues; additionally, expression is typically associated with tumor cell proliferation, progression and/or survival. By blocking the function or expression of the tumor-associated target, the targeted therapy agent may exert potential antineoplastic and/or immunomodulatory activities." @default.
- NCIT_C163758 NCIT_NHC0 "C163758" @default.
- NCIT_C163758 NCIT_P106 "Classification" @default.
- NCIT_C163758 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163758 NCIT_P108 "Targeted Therapy Agent" @default.
- NCIT_C163758 NCIT_P208 "CL976985" @default.
- NCIT_C163758 NCIT_P98 "Includes mainly antibodies, small molecules and antibody-drug conjugates (ADCs). As of September 2019, this therapy agent tree does not include immune cells, such as CAR-T cells, vaccines, gene therapy agents and radio(immuno)conjugates. Targets featured in this tree are the most common targets against which agents are being developed or have been approved. New target/agent categories in this tree will be identified and added based on user needs and new drug developments." @default.
- NCIT_C163758 normalizedInformationContent "47.589121319526839" @default.
- NCIT_C163758 referenceCount "2753" @default.
- NCIT_C163758 hasExactSynonym "Anti-tumor Targeted Therapy Agent" @default.
- NCIT_C163758 hasExactSynonym "Molecularly Targeted Therapy Agent" @default.
- NCIT_C163758 hasExactSynonym "Targeted Agent" @default.
- NCIT_C163758 hasExactSynonym "Targeted Therapeutic Agent" @default.
- NCIT_C163758 hasExactSynonym "Targeted Therapy Agent" @default.
- NCIT_C163758 inSubset NCIT_C128784 @default.
- NCIT_C163758 type Class @default.
- NCIT_C163758 isDefinedBy ncit.owl @default.
- NCIT_C163758 label "Targeted Therapy Agent" @default.
- NCIT_C163758 subClassOf NCIT_C163758 @default.
- NCIT_C163758 subClassOf NCIT_C1908 @default.
- NCIT_C163758 subClassOf NCIT_C1909 @default.
- NCIT_C163758 subClassOf NCIT_C274 @default.