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- NCIT_C163976 IAO_0000115 "An immunoglobulin G4 (IgG4) bispecific antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, voxalatamab simultaneously binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA, a tumor associated antigen, is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.
- NCIT_C163976 NCIT_A32 NCIT_C1909 @default.
- NCIT_C163976 NCIT_A7 NCIT_C17796 @default.
- NCIT_C163976 NCIT_NHC0 "C163976" @default.
- NCIT_C163976 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C163976 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163976 NCIT_P107 "Voxalatamab" @default.
- NCIT_C163976 NCIT_P108 "Voxalatamab" @default.
- NCIT_C163976 NCIT_P208 "CL977249" @default.
- NCIT_C163976 NCIT_P210 "2411871-58-2" @default.
- NCIT_C163976 NCIT_P319 "O257GFG7G0" @default.
- NCIT_C163976 NCIT_P322 "CTRP" @default.
- NCIT_C163976 NCIT_P322 "FDA" @default.
- NCIT_C163976 NCIT_P322 "GDC" @default.
- NCIT_C163976 NCIT_P329 "801628" @default.
- NCIT_C163976 NCIT_P330 "801628" @default.
- NCIT_C163976 NCIT_P375 "Anti-PSMA/CD3 Bispecific Antibody JNJ-63898081" @default.
- NCIT_C163976 NCIT_P399 "801628" @default.
- NCIT_C163976 NCIT_R124 NCIT_C17710 @default.
- NCIT_C163976 NCIT_R124 NCIT_C17828 @default.
- NCIT_C163976 NCIT_R124 NCIT_C18219 @default.
- NCIT_C163976 NCIT_R124 NCIT_C19986 @default.
- NCIT_C163976 NCIT_R124 NCIT_C40474 @default.
- NCIT_C163976 normalizedInformationContent "100" @default.
- NCIT_C163976 referenceCount "1" @default.
- NCIT_C163976 hasExactSynonym "Anti-PSMA/CD3 Bispecific Antibody JNJ-63898081" @default.
- NCIT_C163976 hasExactSynonym "JNJ 63898081" @default.
- NCIT_C163976 hasExactSynonym "JNJ-63898081" @default.
- NCIT_C163976 hasExactSynonym "JNJ-8081" @default.
- NCIT_C163976 hasExactSynonym "JNJ63898081" @default.
- NCIT_C163976 hasExactSynonym "VOXALATAMAB" @default.
- NCIT_C163976 hasExactSynonym "Voxalatamab" @default.
- NCIT_C163976 inSubset NCIT_C116977 @default.
- NCIT_C163976 inSubset NCIT_C116978 @default.
- NCIT_C163976 inSubset NCIT_C128784 @default.
- NCIT_C163976 inSubset NCIT_C157711 @default.
- NCIT_C163976 inSubset NCIT_C157712 @default.
- NCIT_C163976 inSubset NCIT_C176424 @default.
- NCIT_C163976 inSubset NCIT_C177537 @default.
- NCIT_C163976 inSubset NCIT_C63923 @default.
- NCIT_C163976 type Class @default.
- NCIT_C163976 isDefinedBy ncit.owl @default.
- NCIT_C163976 label "Voxalatamab" @default.
- NCIT_C163976 subClassOf NCIT_C112883 @default.
- NCIT_C163976 subClassOf NCIT_C129821 @default.
- NCIT_C163976 subClassOf NCIT_C129822 @default.
- NCIT_C163976 subClassOf NCIT_C1454 @default.
- NCIT_C163976 subClassOf NCIT_C163758 @default.
- NCIT_C163976 subClassOf NCIT_C163976 @default.
- NCIT_C163976 subClassOf NCIT_C176017 @default.
- NCIT_C163976 subClassOf NCIT_C1908 @default.
- NCIT_C163976 subClassOf NCIT_C1909 @default.
- NCIT_C163976 subClassOf NCIT_C201282 @default.
- NCIT_C163976 subClassOf NCIT_C201543 @default.
- NCIT_C163976 subClassOf NCIT_C20401 @default.
- NCIT_C163976 subClassOf NCIT_C274 @default.
- NCIT_C163976 subClassOf NCIT_C28227 @default.
- NCIT_C163976 subClassOf NCIT_C307 @default.
- NCIT_C163976 subClassOf NCIT_C308 @default.