Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C163977> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- NCIT_C163977 IAO_0000115 "A human monoclonal antibody targeting the human cell surface antigen CD47, with potential phagocytosis-inducing and antineoplastic activities. Upon administration, lemzoparlimab preferentially binds to a unique epitope of CD47 on tumor cells. This blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages, which results in macrophage activation and the specific phagocytosis of tumor cells. Additionally, blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response and T-cell-mediated killing of CD47-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate. TJC4, compared to other anti-CD47 monoclonal antibodies, is designed to minimize inherent binding to normal red blood cells (RBCs), which may results in a more advantageous hematologic safety profile." @default.
- NCIT_C163977 NCIT_A32 NCIT_C1909 @default.
- NCIT_C163977 NCIT_A7 NCIT_C25795 @default.
- NCIT_C163977 NCIT_NHC0 "C163977" @default.
- NCIT_C163977 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C163977 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C163977 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163977 NCIT_P107 "Lemzoparlimab" @default.
- NCIT_C163977 NCIT_P108 "Lemzoparlimab" @default.
- NCIT_C163977 NCIT_P208 "CL977248" @default.
- NCIT_C163977 NCIT_P210 "2377483-71-9" @default.
- NCIT_C163977 NCIT_P319 "0H2XLR2IKW" @default.
- NCIT_C163977 NCIT_P322 "CTRP" @default.
- NCIT_C163977 NCIT_P322 "FDA" @default.
- NCIT_C163977 NCIT_P322 "GDC" @default.
- NCIT_C163977 NCIT_P329 "801670" @default.
- NCIT_C163977 NCIT_P330 "801670" @default.
- NCIT_C163977 NCIT_P375 "Anti-CD47 Monoclonal Antibody TJC4" @default.
- NCIT_C163977 NCIT_P399 "801670" @default.
- NCIT_C163977 NCIT_R124 NCIT_C17710 @default.
- NCIT_C163977 NCIT_R124 NCIT_C17828 @default.
- NCIT_C163977 NCIT_R124 NCIT_C18219 @default.
- NCIT_C163977 NCIT_R124 NCIT_C19986 @default.
- NCIT_C163977 NCIT_R124 NCIT_C40474 @default.
- NCIT_C163977 normalizedInformationContent "100" @default.
- NCIT_C163977 referenceCount "1" @default.
- NCIT_C163977 hasExactSynonym "Anti-CD47 Monoclonal Antibody TJC4" @default.
- NCIT_C163977 hasExactSynonym "LEMZOPARLIMAB" @default.
- NCIT_C163977 hasExactSynonym "Lemzoparlimab" @default.
- NCIT_C163977 hasExactSynonym "TJ 011133" @default.
- NCIT_C163977 hasExactSynonym "TJ-011133" @default.
- NCIT_C163977 hasExactSynonym "TJ011133" @default.
- NCIT_C163977 hasExactSynonym "TJC4" @default.
- NCIT_C163977 inSubset NCIT_C116977 @default.
- NCIT_C163977 inSubset NCIT_C116978 @default.
- NCIT_C163977 inSubset NCIT_C128784 @default.
- NCIT_C163977 inSubset NCIT_C157711 @default.
- NCIT_C163977 inSubset NCIT_C157712 @default.
- NCIT_C163977 inSubset NCIT_C176424 @default.
- NCIT_C163977 inSubset NCIT_C177537 @default.
- NCIT_C163977 inSubset NCIT_C63923 @default.
- NCIT_C163977 type Class @default.
- NCIT_C163977 isDefinedBy ncit.owl @default.
- NCIT_C163977 label "Lemzoparlimab" @default.
- NCIT_C163977 subClassOf B080d0c6c9ec9a63ba4e78ce89c40315e @default.
- NCIT_C163977 subClassOf B96920d6129ab2d493a18d3967b5a965d @default.
- NCIT_C163977 subClassOf NCIT_C129821 @default.
- NCIT_C163977 subClassOf NCIT_C129822 @default.
- NCIT_C163977 subClassOf NCIT_C159583 @default.
- NCIT_C163977 subClassOf NCIT_C163758 @default.
- NCIT_C163977 subClassOf NCIT_C163977 @default.
- NCIT_C163977 subClassOf NCIT_C1908 @default.
- NCIT_C163977 subClassOf NCIT_C1909 @default.
- NCIT_C163977 subClassOf NCIT_C192655 @default.
- NCIT_C163977 subClassOf NCIT_C20401 @default.
- NCIT_C163977 subClassOf NCIT_C274 @default.
- NCIT_C163977 subClassOf NCIT_C307 @default.
- NCIT_C163977 subClassOf NCIT_C308 @default.