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- NCIT_C163978 IAO_0000115 "A DNA-based combined formulation composed of INO-5150, DNA plasmids encoding the tumor-associated antigens (TAAs) prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA), and INO-9012, a plasmid DNA vaccine encoding the immune activator and pro-inflammatory cytokine human interleukin-12 (IL-12), with potential immunoactivating and antineoplastic activities. Upon intramuscular delivery of INO-5151 and electroporation of the PSA/PSMA DNA plasmid INO-5150, PSA and PSMA are translated in cells and elicit a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing PSA and PSMA, resulting in tumor cell lysis. Upon electroporation of the DNA plasmid encoding IL-12 INO-9012, IL-12 is translated in cells and the expressed IL-12 activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma (IFN-g) and promoting CTL responses against tumor cells. This boosts the immune response and results in increased CTL-mediated tumor cell death as compared with the administration of INO-5150 alone. PSA and PSMA are overexpressed on a variety of cancer cell types." @default.
- NCIT_C163978 NCIT_A32 NCIT_C1909 @default.
- NCIT_C163978 NCIT_A7 NCIT_C17796 @default.
- NCIT_C163978 NCIT_NHC0 "C163978" @default.
- NCIT_C163978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163978 NCIT_P107 "DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151" @default.
- NCIT_C163978 NCIT_P108 "DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151" @default.
- NCIT_C163978 NCIT_P208 "CL977247" @default.
- NCIT_C163978 NCIT_P322 "CTRP" @default.
- NCIT_C163978 NCIT_P322 "GDC" @default.
- NCIT_C163978 NCIT_P375 "DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151" @default.
- NCIT_C163978 normalizedInformationContent "100" @default.
- NCIT_C163978 referenceCount "1" @default.
- NCIT_C163978 hasExactSynonym "DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151" @default.
- NCIT_C163978 hasExactSynonym "Formulation INO-5150 with INO-9012" @default.
- NCIT_C163978 hasExactSynonym "INO 5151" @default.
- NCIT_C163978 hasExactSynonym "INO-5150 with INO-9012" @default.
- NCIT_C163978 hasExactSynonym "INO-5150/INO-9012 Formulation" @default.
- NCIT_C163978 hasExactSynonym "INO-5151" @default.
- NCIT_C163978 hasExactSynonym "INO5151" @default.
- NCIT_C163978 inSubset NCIT_C116977 @default.
- NCIT_C163978 inSubset NCIT_C116978 @default.
- NCIT_C163978 inSubset NCIT_C128784 @default.
- NCIT_C163978 inSubset NCIT_C157711 @default.
- NCIT_C163978 inSubset NCIT_C157712 @default.
- NCIT_C163978 inSubset NCIT_C177537 @default.
- NCIT_C163978 type Class @default.
- NCIT_C163978 isDefinedBy ncit.owl @default.
- NCIT_C163978 label "DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151" @default.
- NCIT_C163978 subClassOf NCIT_C129820 @default.
- NCIT_C163978 subClassOf NCIT_C163978 @default.
- NCIT_C163978 subClassOf NCIT_C1663 @default.
- NCIT_C163978 subClassOf NCIT_C1908 @default.
- NCIT_C163978 subClassOf NCIT_C1909 @default.
- NCIT_C163978 subClassOf NCIT_C274 @default.
- NCIT_C163978 subClassOf NCIT_C307 @default.
- NCIT_C163978 subClassOf NCIT_C308 @default.
- NCIT_C163978 subClassOf NCIT_C923 @default.