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- NCIT_C163981 IAO_0000115 "A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types." @default.
- NCIT_C163981 NCIT_A32 NCIT_C1909 @default.
- NCIT_C163981 NCIT_A7 NCIT_C17068 @default.
- NCIT_C163981 NCIT_NHC0 "C163981" @default.
- NCIT_C163981 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C163981 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C163981 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C163981 NCIT_P108 "Pimurutamab" @default.
- NCIT_C163981 NCIT_P208 "CL977244" @default.
- NCIT_C163981 NCIT_P210 "2251771-76-1" @default.
- NCIT_C163981 NCIT_P319 "5V1Y8T4RB6" @default.
- NCIT_C163981 NCIT_P322 "FDA" @default.
- NCIT_C163981 NCIT_P322 "GDC" @default.
- NCIT_C163981 NCIT_P329 "799130" @default.
- NCIT_C163981 NCIT_P330 "799130" @default.
- NCIT_C163981 NCIT_P375 "Anti-EGFR Monoclonal Antibody HLX-07" @default.
- NCIT_C163981 NCIT_P375 "Pimurutamab" @default.
- NCIT_C163981 NCIT_P399 "799130" @default.
- NCIT_C163981 NCIT_R124 NCIT_C17710 @default.
- NCIT_C163981 NCIT_R124 NCIT_C17828 @default.
- NCIT_C163981 NCIT_R124 NCIT_C18219 @default.
- NCIT_C163981 NCIT_R124 NCIT_C19986 @default.
- NCIT_C163981 NCIT_R124 NCIT_C40474 @default.
- NCIT_C163981 normalizedInformationContent "100" @default.
- NCIT_C163981 referenceCount "1" @default.
- NCIT_C163981 hasExactSynonym "Anti-EGFR Monoclonal Antibody HLX-07" @default.
- NCIT_C163981 hasExactSynonym "Cetuximab Biobetter HLX07" @default.
- NCIT_C163981 hasExactSynonym "HLX 07" @default.
- NCIT_C163981 hasExactSynonym "HLX-07" @default.
- NCIT_C163981 hasExactSynonym "HLX07" @default.
- NCIT_C163981 hasExactSynonym "PIMURUTAMAB" @default.
- NCIT_C163981 hasExactSynonym "Pimurutamab" @default.
- NCIT_C163981 inSubset NCIT_C128784 @default.
- NCIT_C163981 inSubset NCIT_C157711 @default.
- NCIT_C163981 inSubset NCIT_C157712 @default.
- NCIT_C163981 inSubset NCIT_C176424 @default.
- NCIT_C163981 inSubset NCIT_C177537 @default.
- NCIT_C163981 inSubset NCIT_C63923 @default.
- NCIT_C163981 type Class @default.
- NCIT_C163981 isDefinedBy ncit.owl @default.
- NCIT_C163981 label "Pimurutamab" @default.
- NCIT_C163981 subClassOf NCIT_C129821 @default.
- NCIT_C163981 subClassOf NCIT_C129822 @default.
- NCIT_C163981 subClassOf NCIT_C133878 @default.
- NCIT_C163981 subClassOf NCIT_C163758 @default.
- NCIT_C163981 subClassOf NCIT_C163952 @default.
- NCIT_C163981 subClassOf NCIT_C163981 @default.
- NCIT_C163981 subClassOf NCIT_C1908 @default.
- NCIT_C163981 subClassOf NCIT_C1909 @default.
- NCIT_C163981 subClassOf NCIT_C20401 @default.
- NCIT_C163981 subClassOf NCIT_C274 @default.
- NCIT_C163981 subClassOf NCIT_C307 @default.
- NCIT_C163981 subClassOf NCIT_C308 @default.