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- NCIT_C164146 IAO_0000115 "An orally available synthetic nucleoside analog derived from tetrahydrouridine (THU) and cytidine deaminase inhibitor (CDAi), that can potentially be used to prevent the breakdown of cytidines. Upon oral administration, cedazuridine binds to and inhibits CDA, an enzyme primarily found in the gastrointestinal (GI) tract and liver that catalyzes the deamination of cytidine and cytidine analogs. Given in combination with a cytidine, such as the antineoplastic hypomethylating agent decitabine, it specifically prevents its breakdown and increases its bioavailability and efficacy. In addition, this allows for lower doses of decitabine to be administered, which results in decreased decitabine-associated GI toxicity." @default.
- NCIT_C164146 NCIT_A32 NCIT_C1909 @default.
- NCIT_C164146 NCIT_A7 NCIT_C48963 @default.
- NCIT_C164146 NCIT_NHC0 "C164146" @default.
- NCIT_C164146 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C164146 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C164146 NCIT_P107 "Cedazuridine" @default.
- NCIT_C164146 NCIT_P108 "Cedazuridine" @default.
- NCIT_C164146 NCIT_P208 "CL977331" @default.
- NCIT_C164146 NCIT_P210 "1141397-80-9" @default.
- NCIT_C164146 NCIT_P319 "39IS23Q1EW" @default.
- NCIT_C164146 NCIT_P322 "CTRP" @default.
- NCIT_C164146 NCIT_P322 "FDA" @default.
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- NCIT_C164146 NCIT_P329 "799445" @default.
- NCIT_C164146 NCIT_P330 "799445" @default.
- NCIT_C164146 NCIT_P375 "Cedazuridine" @default.
- NCIT_C164146 NCIT_P399 "799445" @default.
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- NCIT_C164146 NCIT_R146 NCIT_C26548 @default.
- NCIT_C164146 NCIT_R146 NCIT_C48963 @default.
- NCIT_C164146 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C164146 referenceCount "2" @default.
- NCIT_C164146 hasExactSynonym "(4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine" @default.
- NCIT_C164146 hasExactSynonym "CDA Inhibitor E7727" @default.
- NCIT_C164146 hasExactSynonym "CEDAZURIDINE" @default.
- NCIT_C164146 hasExactSynonym "Cedazuridine" @default.
- NCIT_C164146 hasExactSynonym "E7727" @default.
- NCIT_C164146 hasExactSynonym "Uridine, 2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-, (4R)" @default.
- NCIT_C164146 inSubset NCIT_C116977 @default.
- NCIT_C164146 inSubset NCIT_C116978 @default.
- NCIT_C164146 inSubset NCIT_C128784 @default.
- NCIT_C164146 inSubset NCIT_C157711 @default.
- NCIT_C164146 inSubset NCIT_C157712 @default.
- NCIT_C164146 inSubset NCIT_C176424 @default.
- NCIT_C164146 inSubset NCIT_C177537 @default.
- NCIT_C164146 inSubset NCIT_C63923 @default.
- NCIT_C164146 type Class @default.
- NCIT_C164146 isDefinedBy ncit.owl @default.
- NCIT_C164146 label "Cedazuridine" @default.
- NCIT_C164146 subClassOf B0c66b224691d45cb510947cf1b70930c @default.
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- NCIT_C164146 subClassOf NCIT_C164146 @default.
- NCIT_C164146 subClassOf NCIT_C1908 @default.
- NCIT_C164146 subClassOf NCIT_C1909 @default.
- NCIT_C164146 subClassOf NCIT_C2135 @default.
- NCIT_C164146 subClassOf NCIT_C471 @default.