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- NCIT_C164227 IAO_0000115 "An orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion protein, with potential antineoplastic activity. Upon oral administration, ziftomenib prevents the interaction between the two proteins menin and MLL, and thus the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth and proliferation of certain kinds of leukemia cells." @default.
- NCIT_C164227 NCIT_A7 NCIT_C17595 @default.
- NCIT_C164227 NCIT_A7 NCIT_C18051 @default.
- NCIT_C164227 NCIT_NHC0 "C164227" @default.
- NCIT_C164227 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C164227 NCIT_P107 "Ziftomenib" @default.
- NCIT_C164227 NCIT_P108 "Ziftomenib" @default.
- NCIT_C164227 NCIT_P208 "CL977514" @default.
- NCIT_C164227 NCIT_P210 "2134675-36-6" @default.
- NCIT_C164227 NCIT_P319 "4MOD1F4ENC" @default.
- NCIT_C164227 NCIT_P322 "CTRP" @default.
- NCIT_C164227 NCIT_P322 "FDA" @default.
- NCIT_C164227 NCIT_P329 "799439" @default.
- NCIT_C164227 NCIT_P330 "799439" @default.
- NCIT_C164227 NCIT_P399 "799439" @default.
- NCIT_C164227 normalizedInformationContent "100" @default.
- NCIT_C164227 referenceCount "1" @default.
- NCIT_C164227 hasExactSynonym "KO 539" @default.
- NCIT_C164227 hasExactSynonym "KO-539" @default.
- NCIT_C164227 hasExactSynonym "KO539" @default.
- NCIT_C164227 hasExactSynonym "Menin-KMT2A Inhibitor KO 539" @default.
- NCIT_C164227 hasExactSynonym "Menin-MLL Inhibitor KO-539" @default.
- NCIT_C164227 hasExactSynonym "Menin-MLL Interaction Inhibitor KO 539" @default.
- NCIT_C164227 hasExactSynonym "Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor KO 539" @default.
- NCIT_C164227 hasExactSynonym "ZIFTOMENIB" @default.
- NCIT_C164227 hasExactSynonym "Ziftomenib" @default.
- NCIT_C164227 inSubset NCIT_C116977 @default.
- NCIT_C164227 inSubset NCIT_C116978 @default.
- NCIT_C164227 inSubset NCIT_C128784 @default.
- NCIT_C164227 inSubset NCIT_C176424 @default.
- NCIT_C164227 inSubset NCIT_C63923 @default.
- NCIT_C164227 type Class @default.
- NCIT_C164227 isDefinedBy ncit.owl @default.
- NCIT_C164227 label "Ziftomenib" @default.
- NCIT_C164227 subClassOf NCIT_C164227 @default.
- NCIT_C164227 subClassOf NCIT_C185877 @default.
- NCIT_C164227 subClassOf NCIT_C1908 @default.
- NCIT_C164227 subClassOf NCIT_C1909 @default.
- NCIT_C164227 subClassOf NCIT_C2189 @default.
- NCIT_C164227 subClassOf NCIT_C274 @default.