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- NCIT_C16516 IAO_0000115 "DNA topoisomerase 1 (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology." @default.
- NCIT_C16516 NCIT_NHC0 "C16516" @default.
- NCIT_C16516 NCIT_P100 "126420" @default.
- NCIT_C16516 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C16516 NCIT_P106 "Enzyme" @default.
- NCIT_C16516 NCIT_P107 "Topoisomerase I" @default.
- NCIT_C16516 NCIT_P108 "DNA Topoisomerase 1" @default.
- NCIT_C16516 NCIT_P207 "C0012920" @default.
- NCIT_C16516 NCIT_P322 "CDISC" @default.
- NCIT_C16516 NCIT_P322 "CTRP" @default.
- NCIT_C16516 NCIT_P325 "An antigen of the nuclear enzyme topoisomerase 1 encoded by the TOP1 gene that relaxes coiled DNA. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases systemic sclerosis and systemic lupus erythematosus." @default.
- NCIT_C16516 NCIT_P366 "Topoisomerase-I" @default.
- NCIT_C16516 NCIT_P93 "P11387" @default.
- NCIT_C16516 NCIT_P98 "DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus)." @default.
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- NCIT_C16516 NCIT_R54 NCIT_C26591 @default.
- NCIT_C16516 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C16516 referenceCount "15" @default.
- NCIT_C16516 hasExactSynonym "DNA Topoisomerase 1" @default.
- NCIT_C16516 hasExactSynonym "DNA Topoisomerase I" @default.
- NCIT_C16516 hasExactSynonym "EC 5.99.1.2" @default.
- NCIT_C16516 hasExactSynonym "SCL-70" @default.
- NCIT_C16516 hasExactSynonym "Scl-70 Antigen" @default.
- NCIT_C16516 hasExactSynonym "Scleroderma-70" @default.
- NCIT_C16516 hasExactSynonym "TOP1" @default.
- NCIT_C16516 hasExactSynonym "Topo I" @default.
- NCIT_C16516 hasExactSynonym "Topoisomerase (DNA) I" @default.
- NCIT_C16516 hasExactSynonym "Topoisomerase 1" @default.
- NCIT_C16516 hasExactSynonym "Topoisomerase I" @default.
- NCIT_C16516 hasExactSynonym "Topoisomerase, DNA, I" @default.
- NCIT_C16516 hasExactSynonym "Type I DNA Topoisomerase" @default.
- NCIT_C16516 inSubset NCIT_C116977 @default.
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- NCIT_C16516 inSubset NCIT_C61410 @default.
- NCIT_C16516 inSubset NCIT_C66830 @default.
- NCIT_C16516 type Class @default.
- NCIT_C16516 isDefinedBy ncit.owl @default.
- NCIT_C16516 label "DNA Topoisomerase 1" @default.
- NCIT_C16516 subClassOf NCIT_C16516 @default.
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