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- NCIT_C165166 IAO_0000115 "An engineered immunoglobulin M (IgM) bispecific antibody, with potential antineoplastic activity. Imvotamab contains ten high affinity binding domains for the tumor-associated antigen (TAA) CD20, and one binding domain for CD3, a T-cell surface antigen. Upon administration, imvotamab binds to both T-cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B-cells. Additionally, imvotamab induces complement-dependent cytotoxicity (CDC) to a greater extent than anti-CD20/anti-CD3 IgG bispecific antibodies, thereby further enhancing the killing CD20-expressing tumor cells. The extra binding units of imvotamab may bind cancer cells that express relatively low amounts of CD20. Also, compared to IgG format bispecific T-cell engaging antibodies, imvotamab appears to induce less cytokine release, which may reduce the risk of cytokine release syndrome (CRS). CD20 is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies." @default.
- NCIT_C165166 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165166 NCIT_A7 NCIT_C38896 @default.
- NCIT_C165166 NCIT_NHC0 "C165166" @default.
- NCIT_C165166 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C165166 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165166 NCIT_P107 "Imvotamab" @default.
- NCIT_C165166 NCIT_P108 "Imvotamab" @default.
- NCIT_C165166 NCIT_P208 "CL978274" @default.
- NCIT_C165166 NCIT_P210 "2573121-53-4" @default.
- NCIT_C165166 NCIT_P319 "F3HG38I0T1" @default.
- NCIT_C165166 NCIT_P322 "CTRP" @default.
- NCIT_C165166 NCIT_P322 "FDA" @default.
- NCIT_C165166 NCIT_P322 "GDC" @default.
- NCIT_C165166 NCIT_P329 "799710" @default.
- NCIT_C165166 NCIT_P330 "799710" @default.
- NCIT_C165166 NCIT_P375 "Anti-CD20/Anti-CD3 Bispecific IgM Antibody IGM2323" @default.
- NCIT_C165166 NCIT_P399 "799710" @default.
- NCIT_C165166 NCIT_R124 NCIT_C17710 @default.
- NCIT_C165166 NCIT_R124 NCIT_C17828 @default.
- NCIT_C165166 NCIT_R124 NCIT_C18219 @default.
- NCIT_C165166 NCIT_R124 NCIT_C19986 @default.
- NCIT_C165166 NCIT_R124 NCIT_C40474 @default.
- NCIT_C165166 normalizedInformationContent "100" @default.
- NCIT_C165166 referenceCount "1" @default.
- NCIT_C165166 hasExactSynonym "Anti-CD20/Anti-CD3 Bispecific IgM Antibody IGM2323" @default.
- NCIT_C165166 hasExactSynonym "Bispecific CD20xCD3 IgM Antibody IGM2323" @default.
- NCIT_C165166 hasExactSynonym "Bispecific IgM Antibody IGM2323" @default.
- NCIT_C165166 hasExactSynonym "IGM 2323" @default.
- NCIT_C165166 hasExactSynonym "IGM-2323" @default.
- NCIT_C165166 hasExactSynonym "IGM2323" @default.
- NCIT_C165166 hasExactSynonym "IMVOTAMAB" @default.
- NCIT_C165166 hasExactSynonym "IgM Pentamer IGM2323" @default.
- NCIT_C165166 hasExactSynonym "Imvotamab" @default.
- NCIT_C165166 inSubset NCIT_C116977 @default.
- NCIT_C165166 inSubset NCIT_C116978 @default.
- NCIT_C165166 inSubset NCIT_C128784 @default.
- NCIT_C165166 inSubset NCIT_C157711 @default.
- NCIT_C165166 inSubset NCIT_C157712 @default.
- NCIT_C165166 inSubset NCIT_C176424 @default.
- NCIT_C165166 inSubset NCIT_C177537 @default.
- NCIT_C165166 inSubset NCIT_C63923 @default.
- NCIT_C165166 type Class @default.
- NCIT_C165166 isDefinedBy ncit.owl @default.
- NCIT_C165166 label "Imvotamab" @default.
- NCIT_C165166 subClassOf NCIT_C112883 @default.
- NCIT_C165166 subClassOf NCIT_C129821 @default.
- NCIT_C165166 subClassOf NCIT_C129822 @default.
- NCIT_C165166 subClassOf NCIT_C141215 @default.
- NCIT_C165166 subClassOf NCIT_C1454 @default.
- NCIT_C165166 subClassOf NCIT_C163758 @default.
- NCIT_C165166 subClassOf NCIT_C164034 @default.
- NCIT_C165166 subClassOf NCIT_C165166 @default.
- NCIT_C165166 subClassOf NCIT_C1908 @default.
- NCIT_C165166 subClassOf NCIT_C1909 @default.
- NCIT_C165166 subClassOf NCIT_C200711 @default.
- NCIT_C165166 subClassOf NCIT_C201282 @default.
- NCIT_C165166 subClassOf NCIT_C20401 @default.
- NCIT_C165166 subClassOf NCIT_C274 @default.
- NCIT_C165166 subClassOf NCIT_C28227 @default.
- NCIT_C165166 subClassOf NCIT_C307 @default.
- NCIT_C165166 subClassOf NCIT_C308 @default.