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- NCIT_C165199 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon administration, CDK4/6 inhibitor FCN-437 selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1/S transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play key roles in the regulation of both cell cycle progression from the G1-phase into the S-phase and cell proliferation." @default.
- NCIT_C165199 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165199 NCIT_A7 NCIT_C17680 @default.
- NCIT_C165199 NCIT_NHC0 "C165199" @default.
- NCIT_C165199 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165199 NCIT_P107 "CDK4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 NCIT_P108 "CDK4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 NCIT_P208 "CL978411" @default.
- NCIT_C165199 NCIT_P322 "CTRP" @default.
- NCIT_C165199 NCIT_P322 "GDC" @default.
- NCIT_C165199 NCIT_P329 "799711" @default.
- NCIT_C165199 NCIT_P330 "799711" @default.
- NCIT_C165199 NCIT_P375 "CDK4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 NCIT_P399 "799711" @default.
- NCIT_C165199 normalizedInformationContent "100" @default.
- NCIT_C165199 referenceCount "1" @default.
- NCIT_C165199 hasExactSynonym "CDK4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 hasExactSynonym "Cyclin-dependent Kinase 4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 hasExactSynonym "FCN 437" @default.
- NCIT_C165199 hasExactSynonym "FCN-437" @default.
- NCIT_C165199 hasExactSynonym "FCN-437c" @default.
- NCIT_C165199 hasExactSynonym "FCN437" @default.
- NCIT_C165199 inSubset NCIT_C116977 @default.
- NCIT_C165199 inSubset NCIT_C116978 @default.
- NCIT_C165199 inSubset NCIT_C128784 @default.
- NCIT_C165199 inSubset NCIT_C157711 @default.
- NCIT_C165199 inSubset NCIT_C157712 @default.
- NCIT_C165199 inSubset NCIT_C176424 @default.
- NCIT_C165199 inSubset NCIT_C177537 @default.
- NCIT_C165199 type Class @default.
- NCIT_C165199 isDefinedBy ncit.owl @default.
- NCIT_C165199 label "CDK4/6 Inhibitor FCN-437" @default.
- NCIT_C165199 subClassOf NCIT_C129824 @default.
- NCIT_C165199 subClassOf NCIT_C129825 @default.
- NCIT_C165199 subClassOf NCIT_C1404 @default.
- NCIT_C165199 subClassOf NCIT_C163758 @default.
- NCIT_C165199 subClassOf NCIT_C165199 @default.
- NCIT_C165199 subClassOf NCIT_C1908 @default.
- NCIT_C165199 subClassOf NCIT_C1909 @default.
- NCIT_C165199 subClassOf NCIT_C192741 @default.
- NCIT_C165199 subClassOf NCIT_C192742 @default.
- NCIT_C165199 subClassOf NCIT_C2185 @default.
- NCIT_C165199 subClassOf NCIT_C2189 @default.
- NCIT_C165199 subClassOf NCIT_C274 @default.
- NCIT_C165199 subClassOf NCIT_C471 @default.
- NCIT_C165199 subClassOf NCIT_C61074 @default.