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- NCIT_C165266 IAO_0000115 "An orally available selective inhibitor of the delta isoform of phosphatidylinositol 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic activity. Upon oral administration, PI3K delta inhibitor SHC014748M selectively binds to and inhibits PI3K delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K delta over-expressing tumor cells. PI3K delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects." @default.
- NCIT_C165266 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165266 NCIT_NHC0 "C165266" @default.
- NCIT_C165266 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165266 NCIT_P108 "PI3K-delta Inhibitor SHC014748M" @default.
- NCIT_C165266 NCIT_P208 "CL978533" @default.
- NCIT_C165266 NCIT_P322 "GDC" @default.
- NCIT_C165266 NCIT_P329 "799414" @default.
- NCIT_C165266 NCIT_P330 "799414" @default.
- NCIT_C165266 NCIT_P375 "PI3K-delta Inhibitor SHC014748M" @default.
- NCIT_C165266 NCIT_P399 "799414" @default.
- NCIT_C165266 normalizedInformationContent "100" @default.
- NCIT_C165266 referenceCount "1" @default.
- NCIT_C165266 hasExactSynonym "PI3K-delta Inhibitor SHC014748M" @default.
- NCIT_C165266 hasExactSynonym "PI3Kd Inhibitor SHC014748M" @default.
- NCIT_C165266 hasExactSynonym "SHC 014748M" @default.
- NCIT_C165266 hasExactSynonym "SHC-014748M" @default.
- NCIT_C165266 hasExactSynonym "SHC014748M" @default.
- NCIT_C165266 inSubset NCIT_C128784 @default.
- NCIT_C165266 inSubset NCIT_C157711 @default.
- NCIT_C165266 inSubset NCIT_C157712 @default.
- NCIT_C165266 inSubset NCIT_C176424 @default.
- NCIT_C165266 inSubset NCIT_C177537 @default.
- NCIT_C165266 type Class @default.
- NCIT_C165266 isDefinedBy ncit.owl @default.
- NCIT_C165266 label "PI3K-delta Inhibitor SHC014748M" @default.
- NCIT_C165266 subClassOf NCIT_C129824 @default.
- NCIT_C165266 subClassOf NCIT_C129825 @default.
- NCIT_C165266 subClassOf NCIT_C1404 @default.
- NCIT_C165266 subClassOf NCIT_C163758 @default.
- NCIT_C165266 subClassOf NCIT_C165266 @default.
- NCIT_C165266 subClassOf NCIT_C1742 @default.
- NCIT_C165266 subClassOf NCIT_C1908 @default.
- NCIT_C165266 subClassOf NCIT_C1909 @default.
- NCIT_C165266 subClassOf NCIT_C2152 @default.
- NCIT_C165266 subClassOf NCIT_C2189 @default.
- NCIT_C165266 subClassOf NCIT_C274 @default.
- NCIT_C165266 subClassOf NCIT_C471 @default.