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- NCIT_C165274 IAO_0000115 "Autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) containing an anti-T-cell receptor beta constant 1 (TRBC1; T-cell receptor beta-1 chain C region) single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T-lymphocyte cells AUTO4 targets and binds to the TRBC1 expressed on tumor cell surfaces. Subsequently, TRBC1-expressing tumor cells are lysed. In addition, AUTO4 carries the universal RQR8 safety "off" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur." @default.
- NCIT_C165274 NCIT_NHC0 "C165274" @default.
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- NCIT_C165274 NCIT_P108 "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4" @default.
- NCIT_C165274 NCIT_P208 "CL978541" @default.
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- NCIT_C165274 normalizedInformationContent "100" @default.
- NCIT_C165274 referenceCount "1" @default.
- NCIT_C165274 hasExactSynonym "AUTO 4" @default.
- NCIT_C165274 hasExactSynonym "AUTO-4" @default.
- NCIT_C165274 hasExactSynonym "AUTO4" @default.
- NCIT_C165274 hasExactSynonym "Anti-TRBC1 CAR T-cells AUTO4" @default.
- NCIT_C165274 hasExactSynonym "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4" @default.
- NCIT_C165274 hasExactSynonym "RQR8/TRBC1 CAR T Cells AUTO4" @default.
- NCIT_C165274 hasExactSynonym "TRBC1-targeting CAR T Cells AUTO4" @default.
- NCIT_C165274 inSubset NCIT_C176424 @default.
- NCIT_C165274 type Class @default.
- NCIT_C165274 isDefinedBy ncit.owl @default.
- NCIT_C165274 label "Anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing Autologous T-lymphocyte Cells AUTO4" @default.
- NCIT_C165274 subClassOf NCIT_C129820 @default.
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