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- NCIT_C165492 IAO_0000115 "A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX110 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C165492 NCIT_A7 NCIT_C38894 @default.
- NCIT_C165492 NCIT_NHC0 "C165492" @default.
- NCIT_C165492 NCIT_P106 "Cell" @default.
- NCIT_C165492 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165492 NCIT_P107 "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110" @default.
- NCIT_C165492 NCIT_P108 "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110" @default.
- NCIT_C165492 NCIT_P208 "CL978563" @default.
- NCIT_C165492 NCIT_P322 "CTRP" @default.
- NCIT_C165492 NCIT_P329 "799962" @default.
- NCIT_C165492 NCIT_P330 "799962" @default.
- NCIT_C165492 NCIT_P399 "799962" @default.
- NCIT_C165492 normalizedInformationContent "100" @default.
- NCIT_C165492 referenceCount "1" @default.
- NCIT_C165492 hasExactSynonym "Allogeneic Anti-CD19 CAR CRISPR-edited T Cells CTX110" @default.
- NCIT_C165492 hasExactSynonym "Allogeneic Anti-CD19 CAR-T Cells CTX110" @default.
- NCIT_C165492 hasExactSynonym "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110" @default.
- NCIT_C165492 hasExactSynonym "Allogeneic CRISPR-Cas9 Gene-edited CD19-directed CAR T-cells CTX110" @default.
- NCIT_C165492 hasExactSynonym "Allogeneic CRISPR-Cas9-Engineered Anti-CD19 CAR T Cells CTX110" @default.
- NCIT_C165492 hasExactSynonym "CTX 110" @default.
- NCIT_C165492 hasExactSynonym "CTX-110" @default.
- NCIT_C165492 hasExactSynonym "CTX101" @default.
- NCIT_C165492 hasExactSynonym "CTX110" @default.
- NCIT_C165492 inSubset NCIT_C116977 @default.
- NCIT_C165492 inSubset NCIT_C116978 @default.
- NCIT_C165492 inSubset NCIT_C128784 @default.
- NCIT_C165492 inSubset NCIT_C176424 @default.
- NCIT_C165492 type Class @default.
- NCIT_C165492 isDefinedBy ncit.owl @default.
- NCIT_C165492 label "Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110" @default.
- NCIT_C165492 subClassOf NCIT_C129820 @default.
- NCIT_C165492 subClassOf NCIT_C129821 @default.
- NCIT_C165492 subClassOf NCIT_C129826 @default.
- NCIT_C165492 subClassOf NCIT_C137999 @default.
- NCIT_C165492 subClassOf NCIT_C142078 @default.
- NCIT_C165492 subClassOf NCIT_C154231 @default.
- NCIT_C165492 subClassOf NCIT_C165492 @default.
- NCIT_C165492 subClassOf NCIT_C176018 @default.
- NCIT_C165492 subClassOf NCIT_C1908 @default.
- NCIT_C165492 subClassOf NCIT_C1909 @default.
- NCIT_C165492 subClassOf NCIT_C1962 @default.
- NCIT_C165492 subClassOf NCIT_C200765 @default.
- NCIT_C165492 subClassOf NCIT_C274 @default.
- NCIT_C165492 subClassOf NCIT_C28676 @default.
- NCIT_C165492 subClassOf NCIT_C307 @default.
- NCIT_C165492 subClassOf NCIT_C308 @default.