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- NCIT_C165555 IAO_0000115 "An orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells." @default.
- NCIT_C165555 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165555 NCIT_NHC0 "C165555" @default.
- NCIT_C165555 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165555 NCIT_P107 "Alvocidib Prodrug TP-1287" @default.
- NCIT_C165555 NCIT_P108 "Alvocidib Prodrug TP-1287" @default.
- NCIT_C165555 NCIT_P208 "CL978685" @default.
- NCIT_C165555 NCIT_P210 "2044686-42-0" @default.
- NCIT_C165555 NCIT_P319 "7MPP85IIJ3" @default.
- NCIT_C165555 NCIT_P322 "CTRP" @default.
- NCIT_C165555 NCIT_P322 "FDA" @default.
- NCIT_C165555 NCIT_P322 "GDC" @default.
- NCIT_C165555 NCIT_P329 "799663" @default.
- NCIT_C165555 NCIT_P330 "799663" @default.
- NCIT_C165555 NCIT_P375 "Alvocidib Prodrug TP-1287" @default.
- NCIT_C165555 NCIT_P399 "799663" @default.
- NCIT_C165555 normalizedInformationContent "100" @default.
- NCIT_C165555 referenceCount "1" @default.
- NCIT_C165555 hasExactSynonym "Alvocidib Phosphate TP-1287" @default.
- NCIT_C165555 hasExactSynonym "Alvocidib Phosphate" @default.
- NCIT_C165555 hasExactSynonym "Alvocidib Prodrug TP-1287" @default.
- NCIT_C165555 hasExactSynonym "TP 1287" @default.
- NCIT_C165555 hasExactSynonym "TP-1287" @default.
- NCIT_C165555 hasExactSynonym "TP1287" @default.
- NCIT_C165555 inSubset NCIT_C116977 @default.
- NCIT_C165555 inSubset NCIT_C116978 @default.
- NCIT_C165555 inSubset NCIT_C128784 @default.
- NCIT_C165555 inSubset NCIT_C157711 @default.
- NCIT_C165555 inSubset NCIT_C157712 @default.
- NCIT_C165555 inSubset NCIT_C176424 @default.
- NCIT_C165555 inSubset NCIT_C177537 @default.
- NCIT_C165555 inSubset NCIT_C63923 @default.
- NCIT_C165555 type Class @default.
- NCIT_C165555 isDefinedBy ncit.owl @default.
- NCIT_C165555 label "Alvocidib Prodrug TP-1287" @default.
- NCIT_C165555 subClassOf NCIT_C129824 @default.
- NCIT_C165555 subClassOf NCIT_C129825 @default.
- NCIT_C165555 subClassOf NCIT_C1404 @default.
- NCIT_C165555 subClassOf NCIT_C163758 @default.
- NCIT_C165555 subClassOf NCIT_C165555 @default.
- NCIT_C165555 subClassOf NCIT_C1908 @default.
- NCIT_C165555 subClassOf NCIT_C1909 @default.
- NCIT_C165555 subClassOf NCIT_C200258 @default.
- NCIT_C165555 subClassOf NCIT_C2185 @default.
- NCIT_C165555 subClassOf NCIT_C2189 @default.
- NCIT_C165555 subClassOf NCIT_C274 @default.
- NCIT_C165555 subClassOf NCIT_C471 @default.
- NCIT_C165555 subClassOf NCIT_C61074 @default.