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- NCIT_C165598 IAO_0000115 "An antibody-drug conjugate (ADC) comprised of an anti-CD205 (lymphocyte antigen 75; Ly75) humanized immunoglobin G1 (IgG1) monoclonal antibody conjugated to DM4, a maytansinoid microtubule disruptor, via a cleavable N-succinimidyl-4-(2-pyridyldithio) butanoate (SPDB) linker, with potential antineoplastic activity. Upon intravenous administration, anti-CD205 ADC OBT076 specifically targets and binds to CD205, a receptor involved in antigen capture and endocytosis, expressed on tumor cells. Following rapid internalization of the ADC/CD205 complex, OBT076 releases its DM4 payload due to cleavage of the SPDB linker by intracellular proteases. Then the DM4 binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in the inhibition of both cell division and cell growth of CD205-expressing tumor cells. CD205, a type I transmembrane surface glycoprotein belonging to the C-type lectin receptor family, is normally expressed on various antigen-presenting cells (APCs) and some leukocyte sub-populations but it is overexpressed in multiple cancer types where it plays a key role in facilitating metastatic invasion." @default.
- NCIT_C165598 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165598 NCIT_A7 NCIT_C165726 @default.
- NCIT_C165598 NCIT_NHC0 "C165598" @default.
- NCIT_C165598 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165598 NCIT_P107 "Anti-CD205 Antibody-drug Conjugate OBT076" @default.
- NCIT_C165598 NCIT_P108 "Anti-CD205 Antibody-drug Conjugate OBT076" @default.
- NCIT_C165598 NCIT_P208 "CL978811" @default.
- NCIT_C165598 NCIT_P322 "CTRP" @default.
- NCIT_C165598 NCIT_P322 "GDC" @default.
- NCIT_C165598 NCIT_P329 "799986" @default.
- NCIT_C165598 NCIT_P330 "799986" @default.
- NCIT_C165598 NCIT_P375 "Anti-CD205 Antibody-drug Conjugate OBT076" @default.
- NCIT_C165598 NCIT_P399 "799986" @default.
- NCIT_C165598 normalizedInformationContent "100" @default.
- NCIT_C165598 referenceCount "1" @default.
- NCIT_C165598 hasExactSynonym "Anti-CD205 ADC OBT076" @default.
- NCIT_C165598 hasExactSynonym "Anti-CD205 Antibody-drug Conjugate OBT076" @default.
- NCIT_C165598 hasExactSynonym "MEN 1309" @default.
- NCIT_C165598 hasExactSynonym "MEN-1309" @default.
- NCIT_C165598 hasExactSynonym "MEN1309" @default.
- NCIT_C165598 hasExactSynonym "OBT 076" @default.
- NCIT_C165598 hasExactSynonym "OBT-076" @default.
- NCIT_C165598 hasExactSynonym "OBT076" @default.
- NCIT_C165598 inSubset NCIT_C116977 @default.
- NCIT_C165598 inSubset NCIT_C116978 @default.
- NCIT_C165598 inSubset NCIT_C128784 @default.
- NCIT_C165598 inSubset NCIT_C157711 @default.
- NCIT_C165598 inSubset NCIT_C157712 @default.
- NCIT_C165598 inSubset NCIT_C176424 @default.
- NCIT_C165598 inSubset NCIT_C177537 @default.
- NCIT_C165598 type Class @default.
- NCIT_C165598 isDefinedBy ncit.owl @default.
- NCIT_C165598 label "Anti-CD205 Antibody-drug Conjugate OBT076" @default.
- NCIT_C165598 subClassOf NCIT_C129821 @default.
- NCIT_C165598 subClassOf NCIT_C129823 @default.
- NCIT_C165598 subClassOf NCIT_C1512 @default.
- NCIT_C165598 subClassOf NCIT_C165598 @default.
- NCIT_C165598 subClassOf NCIT_C1908 @default.
- NCIT_C165598 subClassOf NCIT_C1909 @default.
- NCIT_C165598 subClassOf NCIT_C274 @default.
- NCIT_C165598 subClassOf NCIT_C307 @default.
- NCIT_C165598 subClassOf NCIT_C308 @default.