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- NCIT_C165621 IAO_0000115 "A self-adjuvanted chimeric recombinant protein vaccine, based on the self-adjuvanting KISIMA immunization platform, composed of three components: the 42 residue fragment Z12, a cell penetrating peptide (CPP) derived from the ZEBRA protein transduction domain, a toll-like receptor (TLR) peptide agonist as an adjuvant and a chimeric cargo, a multiple antigenic domain (MAD; MultiE), that contains an as of yet not disclosed amount of major histocompatibility class (MHC)-restricted peptides derived from as of yet undisclosed tumor-associated antigens (TAAs) that are specific for colorectal cancer (CRC) patients, with potential immunomodulating and antineoplastic activities. Upon administration of ATP128, the Z12 moiety targets, binds to and penetrates antigen-presenting cells (APCs), specifically dendritic cells (DCs) and promotes the loading of the epitopes into the DCs and transports antigenic cargoes into both endosomal and cytosolic compartments. Upon processing and antigen presentation by MHC II and I, the immune system is stimulated and activates specific CD4+ and CD8+ T-cells, respectively, against the multi-epitopes specific for the CRC cells, thereby killing the CRC cells." @default.
- NCIT_C165621 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165621 NCIT_NHC0 "C165621" @default.
- NCIT_C165621 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C165621 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C165621 NCIT_P107 "Therapeutic Cancer Vaccine ATP128" @default.
- NCIT_C165621 NCIT_P108 "Therapeutic Cancer Vaccine ATP128" @default.
- NCIT_C165621 NCIT_P208 "CL978804" @default.
- NCIT_C165621 NCIT_P322 "CTRP" @default.
- NCIT_C165621 NCIT_P322 "GDC" @default.
- NCIT_C165621 NCIT_P329 "799990" @default.
- NCIT_C165621 NCIT_P330 "799990" @default.
- NCIT_C165621 NCIT_P375 "Therapeutic Cancer Vaccine ATP128" @default.
- NCIT_C165621 NCIT_P399 "799990" @default.
- NCIT_C165621 NCIT_R124 NCIT_C17828 @default.
- NCIT_C165621 NCIT_R124 NCIT_C17930 @default.
- NCIT_C165621 NCIT_R124 NCIT_C17937 @default.
- NCIT_C165621 NCIT_R124 NCIT_C18839 @default.
- NCIT_C165621 NCIT_R124 NCIT_C21124 @default.
- NCIT_C165621 NCIT_R124 NCIT_C45548 @default.
- NCIT_C165621 normalizedInformationContent "100" @default.
- NCIT_C165621 referenceCount "1" @default.
- NCIT_C165621 hasExactSynonym "ATP 128" @default.
- NCIT_C165621 hasExactSynonym "ATP-128" @default.
- NCIT_C165621 hasExactSynonym "ATP128" @default.
- NCIT_C165621 hasExactSynonym "Therapeutic Cancer Vaccine ATP128" @default.
- NCIT_C165621 hasExactSynonym "Z12-MultiE/TLR Agonist Domain ATP128" @default.
- NCIT_C165621 inSubset NCIT_C116977 @default.
- NCIT_C165621 inSubset NCIT_C116978 @default.
- NCIT_C165621 inSubset NCIT_C128784 @default.
- NCIT_C165621 inSubset NCIT_C157711 @default.
- NCIT_C165621 inSubset NCIT_C157712 @default.
- NCIT_C165621 inSubset NCIT_C176424 @default.
- NCIT_C165621 inSubset NCIT_C177537 @default.
- NCIT_C165621 type Class @default.
- NCIT_C165621 isDefinedBy ncit.owl @default.
- NCIT_C165621 label "Therapeutic Cancer Vaccine ATP128" @default.
- NCIT_C165621 subClassOf NCIT_C129820 @default.
- NCIT_C165621 subClassOf NCIT_C165621 @default.
- NCIT_C165621 subClassOf NCIT_C1663 @default.
- NCIT_C165621 subClassOf NCIT_C1752 @default.
- NCIT_C165621 subClassOf NCIT_C1908 @default.
- NCIT_C165621 subClassOf NCIT_C1909 @default.
- NCIT_C165621 subClassOf NCIT_C274 @default.
- NCIT_C165621 subClassOf NCIT_C307 @default.
- NCIT_C165621 subClassOf NCIT_C308 @default.
- NCIT_C165621 subClassOf NCIT_C923 @default.