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- NCIT_C165646 IAO_0000115 "A donor-derived, off-the-shelf, microbiome therapeutic cancer peptide vaccine composed of three bacterial onco-mimics, immunogenic microbiome-derived peptides that are highly homologous to tumor-associated antigens (TAAs), that are obtained and selected from the human gut microbiome and are specific for brain tumors, including glioblastoma, with potential immunomodulating and antineoplastic activities. The three microbiome-derived bacterial antigens in EO2401 mimic three TAAs that are highly expressed by brain tumors. Upon administration of microbiome-derived peptide vaccine EO2401, the peptides are taken up by and presented on dendritic cells (DCs) to T-cells. As the presented antigens display molecular mimicry with selected TAAs on brain cancer cells, a memory T-cell and cytotoxic T-lymphocyte (CTL)-mediated immune response may be mounted against the TAAs expressed on the brain cancer cells, thereby eradicating the brain cancer cells." @default.
- NCIT_C165646 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165646 NCIT_NHC0 "C165646" @default.
- NCIT_C165646 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C165646 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165646 NCIT_P107 "Microbiome-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 NCIT_P108 "Microbiome-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 NCIT_P208 "CL978949" @default.
- NCIT_C165646 NCIT_P322 "CTRP" @default.
- NCIT_C165646 NCIT_P322 "GDC" @default.
- NCIT_C165646 NCIT_P329 "799761" @default.
- NCIT_C165646 NCIT_P330 "799761" @default.
- NCIT_C165646 NCIT_P375 "Microbiome-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 NCIT_P399 "799761" @default.
- NCIT_C165646 NCIT_R124 NCIT_C17828 @default.
- NCIT_C165646 NCIT_R124 NCIT_C17930 @default.
- NCIT_C165646 NCIT_R124 NCIT_C17937 @default.
- NCIT_C165646 NCIT_R124 NCIT_C18839 @default.
- NCIT_C165646 NCIT_R124 NCIT_C21124 @default.
- NCIT_C165646 NCIT_R124 NCIT_C45548 @default.
- NCIT_C165646 normalizedInformationContent "100" @default.
- NCIT_C165646 referenceCount "1" @default.
- NCIT_C165646 hasExactSynonym "Cancer Vaccine EO2401" @default.
- NCIT_C165646 hasExactSynonym "EO 2401" @default.
- NCIT_C165646 hasExactSynonym "EO-2401" @default.
- NCIT_C165646 hasExactSynonym "EO2401" @default.
- NCIT_C165646 hasExactSynonym "Microbial-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 hasExactSynonym "Microbiome-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 hasExactSynonym "Microbiome-derived Therapeutic Cancer Vaccine EO2401" @default.
- NCIT_C165646 inSubset NCIT_C116977 @default.
- NCIT_C165646 inSubset NCIT_C116978 @default.
- NCIT_C165646 inSubset NCIT_C128784 @default.
- NCIT_C165646 inSubset NCIT_C157711 @default.
- NCIT_C165646 inSubset NCIT_C157712 @default.
- NCIT_C165646 inSubset NCIT_C176424 @default.
- NCIT_C165646 inSubset NCIT_C177537 @default.
- NCIT_C165646 type Class @default.
- NCIT_C165646 isDefinedBy ncit.owl @default.
- NCIT_C165646 label "Microbiome-derived Peptide Vaccine EO2401" @default.
- NCIT_C165646 subClassOf NCIT_C129820 @default.
- NCIT_C165646 subClassOf NCIT_C165646 @default.
- NCIT_C165646 subClassOf NCIT_C1663 @default.
- NCIT_C165646 subClassOf NCIT_C1752 @default.
- NCIT_C165646 subClassOf NCIT_C1908 @default.
- NCIT_C165646 subClassOf NCIT_C1909 @default.
- NCIT_C165646 subClassOf NCIT_C274 @default.
- NCIT_C165646 subClassOf NCIT_C307 @default.
- NCIT_C165646 subClassOf NCIT_C308 @default.
- NCIT_C165646 subClassOf NCIT_C923 @default.